FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017669487> ?p ?o ?g. }

• W2017669487 endingPage "285" @default.
• W2017669487 startingPage "273" @default.
• W2017669487 abstract "RNA-binding proteins that bind to the 3' untranslated region of mRNAs play important roles in regulating gene expression. Here we examine the association between the 70 kDa poly (A) binding protein (PABP) and stored (RNP) and polysomal mRNAs during mammalian male germ cell development. PABP mRNA levels increase as germ cells enter meiosis, reaching a maximum in the early postmeiotic stages, and decreasing to a nearly nondetectable level towards the end of spermatogenesis. Most of the PABP mRNA is found in the nonpolysomal fractions of postmitochondrial extracts, suggesting that PABP mRNA is either inefficiently translated or stored as RNPs during spermatogenesis. Virtually all of the testicular PABP is bound to either polysomal or nonpolysomal mRNAs, with little, if any, free PABP detectable. Analysis of several specific mRNAs reveals PABP is bound to both stored (RNP) and translated forms of the mRNAs. Western blot analysis and immunocytochemistry indicate PABP is widespread in the mammalian testis, with maximal amounts detected in postmeiotic round spermatids. The presence of PABP in elongating spermatids, a cell type in which PABP mRNA is nearly absent, suggests that PABP is a stable protein in the later stages of male germ cell development. The high level of testicular PABP in round spermatids and in mRNPs suggests a role for PABP in the storage as well as in the subsequent translation of developmentally regulated mRNAs in the mammalian testis." @default.
• W2017669487 created "2016-06-24" @default.
• W2017669487 creator A5017356549 @default.
• W2017669487 creator A5023085602 @default.
• W2017669487 creator A5024858429 @default.
• W2017669487 creator A5026813262 @default.
• W2017669487 creator A5074440551 @default.
• W2017669487 date "1995-03-01" @default.
• W2017669487 modified "2023-10-10" @default.
• W2017669487 title "Poly (A) binding protein is bound to both stored and polysomal mRNAs in the mammalian testis" @default.
• W2017669487 cites W1488368159 @default.
• W2017669487 cites W1563541778 @default.
• W2017669487 cites W1784570168 @default.
• W2017669487 cites W1876038145 @default.
• W2017669487 cites W1906453721 @default.
• W2017669487 cites W1918118064 @default.
• W2017669487 cites W1936434484 @default.
• W2017669487 cites W1958010590 @default.
• W2017669487 cites W1958959715 @default.
• W2017669487 cites W1971421846 @default.
• W2017669487 cites W1982110415 @default.
• W2017669487 cites W1986923567 @default.
• W2017669487 cites W1994369903 @default.
• W2017669487 cites W1997921267 @default.
• W2017669487 cites W2004984690 @default.
• W2017669487 cites W2013774814 @default.
• W2017669487 cites W2023941617 @default.
• W2017669487 cites W2024986501 @default.
• W2017669487 cites W2027899259 @default.
• W2017669487 cites W2028164264 @default.
• W2017669487 cites W2032368489 @default.
• W2017669487 cites W2042067430 @default.
• W2017669487 cites W2042286349 @default.
• W2017669487 cites W2042930581 @default.
• W2017669487 cites W2045202900 @default.
• W2017669487 cites W2045462467 @default.
• W2017669487 cites W2047188621 @default.
• W2017669487 cites W2048003501 @default.
• W2017669487 cites W2049479116 @default.
• W2017669487 cites W2049510621 @default.
• W2017669487 cites W2054694895 @default.
• W2017669487 cites W2066743380 @default.
• W2017669487 cites W2071709406 @default.
• W2017669487 cites W2087483761 @default.
• W2017669487 cites W2092017548 @default.
• W2017669487 cites W2096469776 @default.
• W2017669487 cites W2097639196 @default.
• W2017669487 cites W2114762985 @default.
• W2017669487 cites W2116153438 @default.
• W2017669487 cites W2132017330 @default.
• W2017669487 cites W2151132179 @default.
• W2017669487 cites W2160131677 @default.
• W2017669487 cites W2161169276 @default.
• W2017669487 cites W2171692802 @default.
• W2017669487 cites W2270487047 @default.
• W2017669487 cites W4214931456 @default.
• W2017669487 cites W4249301287 @default.
• W2017669487 doi "https://doi.org/10.1002/mrd.1080400303" @default.
• W2017669487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7772337" @default.
• W2017669487 hasPublicationYear "1995" @default.
• W2017669487 type Work @default.
• W2017669487 sameAs 2017669487 @default.
• W2017669487 citedByCount "48" @default.
• W2017669487 countsByYear W20176694872012 @default.
• W2017669487 countsByYear W20176694872013 @default.
• W2017669487 countsByYear W20176694872014 @default.
• W2017669487 countsByYear W20176694872015 @default.
• W2017669487 countsByYear W20176694872018 @default.
• W2017669487 countsByYear W20176694872020 @default.
• W2017669487 countsByYear W20176694872021 @default.
• W2017669487 countsByYear W20176694872022 @default.
• W2017669487 crossrefType "journal-article" @default.
• W2017669487 hasAuthorship W2017669487A5017356549 @default.
• W2017669487 hasAuthorship W2017669487A5023085602 @default.
• W2017669487 hasAuthorship W2017669487A5024858429 @default.
• W2017669487 hasAuthorship W2017669487A5026813262 @default.
• W2017669487 hasAuthorship W2017669487A5074440551 @default.
• W2017669487 hasConcept C104317684 @default.
• W2017669487 hasConcept C105580179 @default.
• W2017669487 hasConcept C123765429 @default.
• W2017669487 hasConcept C134018914 @default.
• W2017669487 hasConcept C149364088 @default.
• W2017669487 hasConcept C150194340 @default.
• W2017669487 hasConcept C153911025 @default.
• W2017669487 hasConcept C22667442 @default.
• W2017669487 hasConcept C2777394357 @default.
• W2017669487 hasConcept C2779122487 @default.
• W2017669487 hasConcept C2780887552 @default.
• W2017669487 hasConcept C41282012 @default.
• W2017669487 hasConcept C54355233 @default.
• W2017669487 hasConcept C86803240 @default.
• W2017669487 hasConcept C89604277 @default.
• W2017669487 hasConcept C95444343 @default.
• W2017669487 hasConceptScore W2017669487C104317684 @default.
• W2017669487 hasConceptScore W2017669487C105580179 @default.
• W2017669487 hasConceptScore W2017669487C123765429 @default.
• W2017669487 hasConceptScore W2017669487C134018914 @default.
• W2017669487 hasConceptScore W2017669487C149364088 @default.

• next