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• W2017670360 abstract "Drug particulate interactions in pressurized metered dose inhalers (pMDI) may lead to a decrease in aerosolization efficiency and subsequent efficacy in patient treatment. The interactions between salbutamol sulfate (commonly used in Ventolin pMDIs) and a series of pMDI canister materials were investigated using the atomic force microscope (AFM) colloid probe technique. Approximately 4000 individual force-distance curves were determined for a drug probe and three surfaces (10 x 10 mum areas) in situ, in a model propellant. The area under each force-distance curve was integrated to obtain separation energy values. Median separation energy values followed the rank order borosilicate glass > aluminum > PTFE, suggesting PTFE to be the most suitable canister coating." @default.
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• W2017670360 date "2003-06-01" @default.
• W2017670360 modified "2023-10-14" @default.
• W2017670360 title "Under pressure: predicting pressurized metered dose inhaler interactions using the atomic force microscope" @default.
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• W2017670360 doi "https://doi.org/10.1016/s0021-9797(03)00032-8" @default.
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