FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017671182> ?p ?o ?g. }

• W2017671182 endingPage "374" @default.
• W2017671182 startingPage "357" @default.
• W2017671182 abstract "The degradation of the toxic phenol p-cresol by Pseudomonas bacteria occurs by way of the protocatechuate metabolic pathway. The first enzyme in this pathway, p-cresol methylhydroxylase (PCMH), is a flavocytochrome c. The enzyme first catalyzes the oxidation of p-cresol to p-hydroxybenzyl alcohol, utilizing one atom of oxygen derived from water, and yielding one molecule of reduced FAD. The reducing electron equivalents are then passed one at a time from the flavin cofactor to the heme cofactor by intramolecular electron transfer, and subsequently to cytochrome oxidase within the periplasmic membrane via one or more soluble electron carrier proteins. The product, p-hydroxybenzyl alcohol, can also be oxidized by PCMH to yield p-hydroxybenzaldehyde. The fully refined X-ray crystal structure of PCMH in the native state has been obtained at 2. 5 A resolution on the basis of the gene sequence. The structure of the enzyme-substrate complex has also been refined, at 2.75 A resolution, and reveals significant conformational changes in the active site upon substrate binding. The active site for substrate oxidation is deeply buried in the interior of the PCMH molecule. A route for substrate access to the site has been identified and is shown to be governed by a swinging-gate mechanism. Two possible proton transfer pathways, that may assist in activating the substrate for nucleophilic attack and in removal of protons generated during the reaction, have been revealed. Hydrogen bonding interactions between the flavoprotein and cytochrome subunits that stabilize the intramolecular complex and may contribute to the electron transfer process have been identified." @default.
• W2017671182 created "2016-06-24" @default.
• W2017671182 creator A5008061467 @default.
• W2017671182 creator A5020567258 @default.
• W2017671182 creator A5027487424 @default.
• W2017671182 creator A5038287136 @default.
• W2017671182 creator A5044655353 @default.
• W2017671182 creator A5056766535 @default.
• W2017671182 date "2000-01-01" @default.
• W2017671182 modified "2023-10-03" @default.
• W2017671182 title "Structures of the flavocytochrome p-cresol methylhydroxylase and its enzyme-substrate complex: gated substrate entry and proton relays support the proposed catalytic mechanism" @default.
• W2017671182 cites W1264344684 @default.
• W2017671182 cites W1546896179 @default.
• W2017671182 cites W1561702871 @default.
• W2017671182 cites W1599966811 @default.
• W2017671182 cites W189861307 @default.
• W2017671182 cites W1969345643 @default.
• W2017671182 cites W1970269905 @default.
• W2017671182 cites W1981381364 @default.
• W2017671182 cites W1986191025 @default.
• W2017671182 cites W1988331437 @default.
• W2017671182 cites W1993720367 @default.
• W2017671182 cites W1995017064 @default.
• W2017671182 cites W2001952299 @default.
• W2017671182 cites W2013871366 @default.
• W2017671182 cites W2022681616 @default.
• W2017671182 cites W2024435162 @default.
• W2017671182 cites W2024973460 @default.
• W2017671182 cites W2031338911 @default.
• W2017671182 cites W2032421825 @default.
• W2017671182 cites W2033662678 @default.
• W2017671182 cites W2035156848 @default.
• W2017671182 cites W2039055932 @default.
• W2017671182 cites W2049521571 @default.
• W2017671182 cites W2049599835 @default.
• W2017671182 cites W2053427143 @default.
• W2017671182 cites W2056782864 @default.
• W2017671182 cites W2057232866 @default.
• W2017671182 cites W2063063444 @default.
• W2017671182 cites W2065355068 @default.
• W2017671182 cites W2076082000 @default.
• W2017671182 cites W2079364294 @default.
• W2017671182 cites W2086670417 @default.
• W2017671182 cites W2090725298 @default.
• W2017671182 cites W2103794058 @default.
• W2017671182 cites W2161214077 @default.
• W2017671182 cites W22071661 @default.
• W2017671182 cites W2283442761 @default.
• W2017671182 cites W2373667837 @default.
• W2017671182 cites W4239023878 @default.
• W2017671182 cites W6558883 @default.
• W2017671182 cites W6672265 @default.
• W2017671182 doi "https://doi.org/10.1006/jmbi.1999.3290" @default.
• W2017671182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10623531" @default.
• W2017671182 hasPublicationYear "2000" @default.
• W2017671182 type Work @default.
• W2017671182 sameAs 2017671182 @default.
• W2017671182 citedByCount "84" @default.
• W2017671182 countsByYear W20176711822012 @default.
• W2017671182 countsByYear W20176711822013 @default.
• W2017671182 countsByYear W20176711822014 @default.
• W2017671182 countsByYear W20176711822015 @default.
• W2017671182 countsByYear W20176711822016 @default.
• W2017671182 countsByYear W20176711822017 @default.
• W2017671182 countsByYear W20176711822018 @default.
• W2017671182 countsByYear W20176711822019 @default.
• W2017671182 countsByYear W20176711822020 @default.
• W2017671182 countsByYear W20176711822021 @default.
• W2017671182 countsByYear W20176711822022 @default.
• W2017671182 countsByYear W20176711822023 @default.
• W2017671182 crossrefType "journal-article" @default.
• W2017671182 hasAuthorship W2017671182A5008061467 @default.
• W2017671182 hasAuthorship W2017671182A5020567258 @default.
• W2017671182 hasAuthorship W2017671182A5027487424 @default.
• W2017671182 hasAuthorship W2017671182A5038287136 @default.
• W2017671182 hasAuthorship W2017671182A5044655353 @default.
• W2017671182 hasAuthorship W2017671182A5056766535 @default.
• W2017671182 hasConcept C123669783 @default.
• W2017671182 hasConcept C161790260 @default.
• W2017671182 hasConcept C181199279 @default.
• W2017671182 hasConcept C185592680 @default.
• W2017671182 hasConcept C18903297 @default.
• W2017671182 hasConcept C197957613 @default.
• W2017671182 hasConcept C2777289219 @default.
• W2017671182 hasConcept C2779268744 @default.
• W2017671182 hasConcept C33093398 @default.
• W2017671182 hasConcept C41183919 @default.
• W2017671182 hasConcept C55493867 @default.
• W2017671182 hasConcept C63338738 @default.
• W2017671182 hasConcept C71240020 @default.
• W2017671182 hasConcept C71995715 @default.
• W2017671182 hasConcept C75473681 @default.
• W2017671182 hasConcept C86803240 @default.
• W2017671182 hasConceptScore W2017671182C123669783 @default.
• W2017671182 hasConceptScore W2017671182C161790260 @default.
• W2017671182 hasConceptScore W2017671182C181199279 @default.
• W2017671182 hasConceptScore W2017671182C185592680 @default.
• W2017671182 hasConceptScore W2017671182C18903297 @default.

• next