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• W2017672080 endingPage "680" @default.
• W2017672080 startingPage "670" @default.
• W2017672080 abstract "Novobiocin, an aminocoumarin antibiotic, interferes with heat shock protein 90 and hypoxia inducible factor dependent gene expression and thus compromises cell survival. Similar to survival of nucleated cells, erythrocyte survival could be disrupted by eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and by phospholipd scrambling of the cell membrane with phosphatidylserine translocation to the erythrocyte surface. Triggers of eryptosis include increase of cytosolic Ca(2+)-activity ([Ca(2+)]i). The Ca(2+) sensitivity of phospholipid scrambling is enhanced by ceramide. The present study explored, whether novobiocin elicits eryptosis.[Ca(2+)]i was estimated from Fluo3-fluorescence, ceramide abundance utilizing fluorescent antibodies, cell volume from forward scatter, phosphatidylserine-exposure from annexin V binding.A 48 hours exposure to novobiocin (500 µM) was followed by a significant increase of [Ca(2+)]i, decrease of forward scatter, increase of annexin-V-binding and enhanced ceramide formation. Removal of extracellular Ca(2+) virtually abrogated the increase of annexin-V-binding following novobiocin exposure.Novobiocin stimulates eryptosis, an effect at least in part due to entry of extracellular Ca(2+) and formation of ceramide." @default.
• W2017672080 created "2016-06-24" @default.
• W2017672080 creator A5004091570 @default.
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• W2017672080 creator A5074984532 @default.
• W2017672080 creator A5084208566 @default.
• W2017672080 date "2014-01-01" @default.
• W2017672080 modified "2023-09-24" @default.
• W2017672080 title "Induction of Suicidal Erythrocyte Death by Novobiocin" @default.
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