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- W2017672904 endingPage "365" @default.
- W2017672904 startingPage "353" @default.
- W2017672904 abstract "Chemical synapses transmit gustatory signals from taste receptor cells to sensory afferent axons. Chemical (and electrical) synapses also provide a lateral pathway for cells within the taste bud to communicate. Lateral synaptic pathways may represent some form of signal processing in the peripheral end organs of taste. Efferent synaptic input may also regulate sensory transduction in taste buds. To date, the synaptic neurotransmitter(s) or neuromodulator(s) released at chemical synapses in taste buds have not been identified unambiguously. This paper summarizes the attempts that have been made over the past 40 years to identify the neuroactive substances acting at taste bud synapses. We review the four traditional criteria for identifying chemical transmitters elsewhere in the nervous system-localization, uptake/degradation, release and physiological actions- and apply these criteria to neuroactive substances in taste buds. The most complete evidence to date implicates serotonin as a neuromodulator of taste transduction in the end organs. However, studies also suggest that adrenergic, cholinergic and peptidergic neurotransmission may be involved in taste buds." @default.
- W2017672904 created "2016-06-24" @default.
- W2017672904 creator A5026593981 @default.
- W2017672904 creator A5046626462 @default.
- W2017672904 creator A5049752017 @default.
- W2017672904 creator A5066904083 @default.
- W2017672904 date "1996-01-01" @default.
- W2017672904 modified "2023-10-02" @default.
- W2017672904 title "Neuromodulation of Transduction and Signal Processing in the End Organs of Taste" @default.
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- W2017672904 doi "https://doi.org/10.1093/chemse/21.3.353" @default.
- W2017672904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8670715" @default.
- W2017672904 hasPublicationYear "1996" @default.