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- W2017675013 abstract "The concept of auto-immune hepatitis as a disease entity evolved from the descriptions of ‘chronic active hepatitis’ (CAH) in the 1950s. Several types of CAH are distinguished by disease-specific features. The distinctive (but not exclusive) markers for auto-immune CAH include: a negative test for HBsAg; female; Northern European ethnic background; multisystem disease expression; histological CAH with large areas of periportal piecemeal necrosis and plasmacytosis; pronounced hypergammaglobulinaemia; serum auto-antibodies; the HLA B8-DR3 phenotype; responsiveness to corticosteroid therapy; and rarity of supervening hepatocellular carcinoma. Much weight is attached to the serological marker auto-antibodies to nuclear or smooth muscle (actin) antigens (ANA, SMA). However, these auto-antibodies do not have an absolute association with auto-immune CAH: the serological reactions are not yet standardized; titres decrease with remission of disease; and other auto-antibodies mark variant forms of auto-immune hepatitis. A more confident acceptance of auto-immune hepatitis as an entity requires detection of a liver-specific antigen, a valid experimental disease model in animals, and a better understanding of immune-mediated damage to liver cells." @default.
- W2017675013 created "2016-06-24" @default.
- W2017675013 creator A5073399902 @default.
- W2017675013 date "1990-06-01" @default.
- W2017675013 modified "2023-10-16" @default.
- W2017675013 title "Auto-immune (lupoid) hepatitis: An entity in the spectrum of chronic active liver disease" @default.
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- W2017675013 doi "https://doi.org/10.1111/j.1440-1746.1990.tb01637.x" @default.
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