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- W2017675684 abstract "Dual-label radiochemical methods for liquid chromatography are described. Two sets of compounds are used, each set with a different isotopic label. The procedures decrease quantitative uncertainties by as much as 30% for samples in which chemical reactions have altered a test compound in compared biological systems. This advantage is especially useful in toxicologic metabolism studies. Determinations or comparisons of several conjugated and unconjugated metabolites are achieved by extraction and high-performance liquid chromatography based on these procedures. Quantitative procedures that include an internal standard, biologically generated by rats exposed to radiolabeled compounds, are used. By means of these internal standards, metabolite concentrations are compared for test organisms, and results are obtained for metabolites common to both organisms. Effects of impurities, isotope exchange, or chemical kinetics are also evaluated utilizing a modification of the technique." @default.
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- W2017675684 title "Biogenic internal standards for duall-label radiochemical detection of metabolites in liquid chromatography" @default.
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- W2017675684 doi "https://doi.org/10.1016/0003-2670(83)80014-2" @default.
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