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- W2017678418 abstract "Abstract Radiolabeled fatty acids are used as tracers for myocardial metabolic imaging and currently 123 I‐iodophenyl pentadecanoic acid (IPPA) or 123 I‐ β ‐methyl‐iodophenyl pentadecanoic acid (BMIPP) are the agents of choice. However, 123 I being a cyclotron‐produced isotope, 99m Tc‐labeled fatty acids are more desirable substitutes to 123 I‐labeled fatty acids. Toward this, two fatty acids, having 11 and 12 carbon atoms respectively, modified with cysteine were synthesized in a four‐step procedure. These ligands were then radiolabeled with 99m Tc using the [ 99m TcN(PNP6)] 2+ core. Formation of the complexes and determination of radiochemical yields were ascertained by HPLC technique. In vivo distribution of the complexes was carried out in Swiss mice and the results are compared with 125 I‐IPPA. Both the complexes showed fast clearance from the myocardium till 10 min post injection (p.i.) followed by retention in the myocardium till 30 min p.i. However, compared with the result obtained with 125 I‐IPPA, the amount of activity retained in the myocardium by the present complexes were low. Both the complexes showed rapid clearance from liver, lungs, and blood unlike the case with 125 I‐IPPA. Copyright © 2010 John Wiley & Sons, Ltd." @default.
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- W2017678418 date "2010-06-17" @default.
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- W2017678418 title "Evaluation of new positively charged 11- and 12-carbon 99mTc-labeled fatty acid derivatives for myocardial imaging" @default.
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- W2017678418 doi "https://doi.org/10.1002/jlcr.1784" @default.
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