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- W2017678741 abstract "Role of Src kinases in acute lymphoblastic leukaemia has been recently demonstrated in leukaemia mouse model. Retained activation of Src kinases by the BCR-ABL oncoprotein in leukaemic cells following inhibition of BCR-ABL kinase activity by imatinib indicates that Src activation by BCR-ABL is independent of BCR-ABL kinase activity and provides an explanation for reduced effectiveness of the BCR-ABL kinase activity inhibitors in Philadelphia chromosome-positive acute lymphoblastic leukaemia. Simultaneous inhibition of kinase activity of both BCR-ABL and Src kinases results in long-term survival of mice with acute lymphoblastic leukaemia. Leukaemic stem cells exist in acute lymphoblastic leukaemia, and complete eradication of this group of cells would provide a curative therapy for this disease." @default.
- W2017678741 created "2016-06-24" @default.
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- W2017678741 date "2007-07-01" @default.
- W2017678741 modified "2023-10-18" @default.
- W2017678741 title "Src kinase signaling in leukaemia" @default.
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- W2017678741 doi "https://doi.org/10.1016/j.biocel.2007.01.027" @default.
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