FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017679057> ?p ?o ?g. }

• W2017679057 endingPage "1342" @default.
• W2017679057 startingPage "1333" @default.
• W2017679057 abstract "The aim of the present study was to investigate the role of complement activation in the pathogenesis of neuropathic pain (NPP) induced by peripheral nerve injury. We modified a classical chronic constriction injury (CCI) model (mCCI), and verified its reliability in rats. Furthermore, reverse transcription-PCR and immunohistochemistry were conducted to investigate complement activation in the spinal dorsal horn and the effect of a complement inhibitor, cobra venom factor (CVF), on the behavior of the mCCI model rats. We found that rats in the mCCI group presented a better general condition, without signs of autophagy of the toes. Moreover, mCCI induced a significant increase (+40%) in the expression of component 3 (C3) mRNA in the spinal dorsal horn, which was associated with hyperalgesia. Correlation analysis showed a negative correlation between the mechanical pain threshold and the expression of C3 in the spinal cord. Administration of CVF reduced the occurrence of hyperalgesia in mCCI rats and nearly reversed the hyperalgesia. In addition, the mCCI rats exhibited significantly less spinal superoxide dismutase activity and significantly greater levels of maleic dialdehyde compared to the sham-operated rats. Transmission electron micrographs revealed mitochondrial swelling, cell membrane damage, and cristae fragmentation in the neurons of the spinal dorsal horn 14 days after mCCI. Mitochondrial swelling was attenuated in mCCI rats receiving CVF. The findings demonstrated that abnormal complement activation occurred in the dorsal horn of the spinal cord in rats with NPP, and C3 in the spinal dorsal horn could play an important role in the cascade reaction of complements that are involved in the development of hyperalgesia." @default.
• W2017679057 created "2016-06-24" @default.
• W2017679057 creator A5010470652 @default.
• W2017679057 creator A5010599733 @default.
• W2017679057 creator A5011769423 @default.
• W2017679057 creator A5014539863 @default.
• W2017679057 creator A5017412457 @default.
• W2017679057 creator A5044022943 @default.
• W2017679057 creator A5057872518 @default.
• W2017679057 creator A5064804232 @default.
• W2017679057 date "2013-04-11" @default.
• W2017679057 modified "2023-10-05" @default.
• W2017679057 title "Abnormal activation of complement C3 in the spinal dorsal horn is closely associated with progression of neuropathic pain" @default.
• W2017679057 cites W1601370958 @default.
• W2017679057 cites W1966181714 @default.
• W2017679057 cites W1971094792 @default.
• W2017679057 cites W1980219722 @default.
• W2017679057 cites W1987746232 @default.
• W2017679057 cites W1990738990 @default.
• W2017679057 cites W1991283674 @default.
• W2017679057 cites W1996196990 @default.
• W2017679057 cites W1996481470 @default.
• W2017679057 cites W1998657116 @default.
• W2017679057 cites W1998863234 @default.
• W2017679057 cites W2016621275 @default.
• W2017679057 cites W2017271614 @default.
• W2017679057 cites W2022052400 @default.
• W2017679057 cites W2028269583 @default.
• W2017679057 cites W2040299088 @default.
• W2017679057 cites W2042432068 @default.
• W2017679057 cites W2047010161 @default.
• W2017679057 cites W2054410657 @default.
• W2017679057 cites W2058020736 @default.
• W2017679057 cites W2061947329 @default.
• W2017679057 cites W2063380270 @default.
• W2017679057 cites W2072137957 @default.
• W2017679057 cites W2072237144 @default.
• W2017679057 cites W2080428103 @default.
• W2017679057 cites W2092595668 @default.
• W2017679057 cites W2092918915 @default.
• W2017679057 cites W2103351070 @default.
• W2017679057 cites W2104063702 @default.
• W2017679057 cites W2109982451 @default.
• W2017679057 cites W2123219540 @default.
• W2017679057 cites W2126575561 @default.
• W2017679057 cites W2134796495 @default.
• W2017679057 cites W2140821992 @default.
• W2017679057 cites W2142953265 @default.
• W2017679057 cites W2151019621 @default.
• W2017679057 cites W2160779124 @default.
• W2017679057 cites W2163268391 @default.
• W2017679057 cites W315197452 @default.
• W2017679057 doi "https://doi.org/10.3892/ijmm.2013.1344" @default.
• W2017679057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23588254" @default.
• W2017679057 hasPublicationYear "2013" @default.
• W2017679057 type Work @default.
• W2017679057 sameAs 2017679057 @default.
• W2017679057 citedByCount "9" @default.
• W2017679057 countsByYear W20176790572014 @default.
• W2017679057 countsByYear W20176790572015 @default.
• W2017679057 countsByYear W20176790572016 @default.
• W2017679057 countsByYear W20176790572021 @default.
• W2017679057 countsByYear W20176790572022 @default.
• W2017679057 crossrefType "journal-article" @default.
• W2017679057 hasAuthorship W2017679057A5010470652 @default.
• W2017679057 hasAuthorship W2017679057A5010599733 @default.
• W2017679057 hasAuthorship W2017679057A5011769423 @default.
• W2017679057 hasAuthorship W2017679057A5014539863 @default.
• W2017679057 hasAuthorship W2017679057A5017412457 @default.
• W2017679057 hasAuthorship W2017679057A5044022943 @default.
• W2017679057 hasAuthorship W2017679057A5057872518 @default.
• W2017679057 hasAuthorship W2017679057A5064804232 @default.
• W2017679057 hasBestOaLocation W20176790571 @default.
• W2017679057 hasConcept C101762097 @default.
• W2017679057 hasConcept C104317684 @default.
• W2017679057 hasConcept C118552586 @default.
• W2017679057 hasConcept C126322002 @default.
• W2017679057 hasConcept C134018914 @default.
• W2017679057 hasConcept C150194340 @default.
• W2017679057 hasConcept C15490471 @default.
• W2017679057 hasConcept C157880135 @default.
• W2017679057 hasConcept C170493617 @default.
• W2017679057 hasConcept C185592680 @default.
• W2017679057 hasConcept C2777107010 @default.
• W2017679057 hasConcept C2779245659 @default.
• W2017679057 hasConcept C2780775167 @default.
• W2017679057 hasConcept C2781149210 @default.
• W2017679057 hasConcept C42219234 @default.
• W2017679057 hasConcept C55493867 @default.
• W2017679057 hasConcept C71924100 @default.
• W2017679057 hasConceptScore W2017679057C101762097 @default.
• W2017679057 hasConceptScore W2017679057C104317684 @default.
• W2017679057 hasConceptScore W2017679057C118552586 @default.
• W2017679057 hasConceptScore W2017679057C126322002 @default.
• W2017679057 hasConceptScore W2017679057C134018914 @default.
• W2017679057 hasConceptScore W2017679057C150194340 @default.
• W2017679057 hasConceptScore W2017679057C15490471 @default.
• W2017679057 hasConceptScore W2017679057C157880135 @default.

• next