FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017684403> ?p ?o ?g. }

• W2017684403 endingPage "e70952" @default.
• W2017684403 startingPage "e70952" @default.
• W2017684403 abstract "Glycogen synthase kinase-3 (GSK-3) inhibitors have been postulated as useful therapeutic tools for the treatment of chronic neurodegenerative and neuropsychiatric diseases. Nevertheless the clinical use of these inhibitors has been limited by their common side effects. Lithium, a non-selective GSK-3 inhibitor has been classically administered to treat bipolar patients but its prescription is decreasing due to its frequent side effects such as hand tremor. This toxicity seems to be higher in the elderly and a clinical trial with lithium for Alzheimer’s disease was stopped due to high rate of discontinuation. We have previously described a mechanism for the adverse effects of chronic lithium that involves neuronal apoptosis via Fas signaling. As lithium inhibits many other enzymatic activities such as inositol monophosphatase and histone deacetylase, here we aim to genetically test whether GSK-3 inhibition induces those adverse effects through Fas receptor. For this purpose we took advantage of a transgenic mouse line with decreased GSK-3 activity (Tet/DN-GSK-3 mice) that shows increased rate of neuronal apoptosis as well as motor deficits and brought it to a Fas deficient background (lpr mice). We found that apoptosis induced by GSK-3 inhibition was absent in Fas deficient background. Interestingly, motor deficits were also absent in Fas deficient Tet/DN-GSK-3 mice. These results demonstrate that Fas signaling contributes to the neurological toxicity of GSK-3 inhibition and suggest that a combination of GSK-3 inhibitors with blockers of Fas signaling could help to improve the application of GSK-3 inhibitors to clinics." @default.
• W2017684403 created "2016-06-24" @default.
• W2017684403 creator A5019340831 @default.
• W2017684403 creator A5048199372 @default.
• W2017684403 date "2013-08-05" @default.
• W2017684403 modified "2023-09-26" @default.
• W2017684403 title "Neuronal Apoptosis and Motor Deficits in Mice with Genetic Inhibition of GSK-3 Are Fas-Dependent" @default.
• W2017684403 cites W124123819 @default.
• W2017684403 cites W1489736060 @default.
• W2017684403 cites W1546578130 @default.
• W2017684403 cites W1577837690 @default.
• W2017684403 cites W1960647274 @default.
• W2017684403 cites W1964799699 @default.
• W2017684403 cites W1968899142 @default.
• W2017684403 cites W1970656224 @default.
• W2017684403 cites W1972343960 @default.
• W2017684403 cites W1979993283 @default.
• W2017684403 cites W1990701803 @default.
• W2017684403 cites W1991992154 @default.
• W2017684403 cites W1995540460 @default.
• W2017684403 cites W1998772348 @default.
• W2017684403 cites W1999840793 @default.
• W2017684403 cites W2000962656 @default.
• W2017684403 cites W2008584595 @default.
• W2017684403 cites W2017394604 @default.
• W2017684403 cites W2029643611 @default.
• W2017684403 cites W2034595626 @default.
• W2017684403 cites W2037053607 @default.
• W2017684403 cites W2038669173 @default.
• W2017684403 cites W2048146741 @default.
• W2017684403 cites W2051788298 @default.
• W2017684403 cites W2052384228 @default.
• W2017684403 cites W2055303877 @default.
• W2017684403 cites W2058459224 @default.
• W2017684403 cites W2063527418 @default.
• W2017684403 cites W2063620211 @default.
• W2017684403 cites W2064913654 @default.
• W2017684403 cites W2070820741 @default.
• W2017684403 cites W2077975299 @default.
• W2017684403 cites W2079090986 @default.
• W2017684403 cites W2080869790 @default.
• W2017684403 cites W2082042799 @default.
• W2017684403 cites W2083308747 @default.
• W2017684403 cites W2088434373 @default.
• W2017684403 cites W2092995930 @default.
• W2017684403 cites W2093189569 @default.
• W2017684403 cites W2095238537 @default.
• W2017684403 cites W2101141112 @default.
• W2017684403 cites W2103708669 @default.
• W2017684403 cites W2109052112 @default.
• W2017684403 cites W2125904354 @default.
• W2017684403 cites W2128348740 @default.
• W2017684403 cites W2132442335 @default.
• W2017684403 cites W2159523762 @default.
• W2017684403 cites W2166036638 @default.
• W2017684403 cites W2179862924 @default.
• W2017684403 cites W2334309409 @default.
• W2017684403 cites W2497724876 @default.
• W2017684403 cites W4256264762 @default.
• W2017684403 doi "https://doi.org/10.1371/journal.pone.0070952" @default.
• W2017684403 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3734180" @default.
• W2017684403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23940673" @default.
• W2017684403 hasPublicationYear "2013" @default.
• W2017684403 type Work @default.
• W2017684403 sameAs 2017684403 @default.
• W2017684403 citedByCount "5" @default.
• W2017684403 countsByYear W20176844032015 @default.
• W2017684403 countsByYear W20176844032017 @default.
• W2017684403 countsByYear W20176844032018 @default.
• W2017684403 crossrefType "journal-article" @default.
• W2017684403 hasAuthorship W2017684403A5019340831 @default.
• W2017684403 hasAuthorship W2017684403A5048199372 @default.
• W2017684403 hasBestOaLocation W20176844031 @default.
• W2017684403 hasConcept C104629339 @default.
• W2017684403 hasConcept C126322002 @default.
• W2017684403 hasConcept C134018914 @default.
• W2017684403 hasConcept C182996813 @default.
• W2017684403 hasConcept C190283241 @default.
• W2017684403 hasConcept C192118531 @default.
• W2017684403 hasConcept C2779306644 @default.
• W2017684403 hasConcept C55493867 @default.
• W2017684403 hasConcept C62478195 @default.
• W2017684403 hasConcept C71924100 @default.
• W2017684403 hasConcept C86803240 @default.
• W2017684403 hasConcept C95444343 @default.
• W2017684403 hasConcept C98274493 @default.
• W2017684403 hasConceptScore W2017684403C104629339 @default.
• W2017684403 hasConceptScore W2017684403C126322002 @default.
• W2017684403 hasConceptScore W2017684403C134018914 @default.
• W2017684403 hasConceptScore W2017684403C182996813 @default.
• W2017684403 hasConceptScore W2017684403C190283241 @default.
• W2017684403 hasConceptScore W2017684403C192118531 @default.
• W2017684403 hasConceptScore W2017684403C2779306644 @default.
• W2017684403 hasConceptScore W2017684403C55493867 @default.
• W2017684403 hasConceptScore W2017684403C62478195 @default.
• W2017684403 hasConceptScore W2017684403C71924100 @default.
• W2017684403 hasConceptScore W2017684403C86803240 @default.
• W2017684403 hasConceptScore W2017684403C95444343 @default.

• next