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- W2017684449 abstract "Abstract A sensitive method is described for the analysis of arylhydroxylamines (derived metabolically from arylamines and nitro compounds) in liver homogenates. The procedure is based on initial extraction of the analyte from the biological matrix with dichloromethane; derivatization in the extraction solvent with p-dimethylaminophenylisocyanate to form a hydroxyurea which is subsequently separated from coextracted materials and reaction by-products by high-performance liquid chromatography (HPLC). The hydroxylamine, itself, is quite unstable [t 1 2 = 8 min in pH 7.4 phosphate buffer (0.1 M; μ = 0.5)]; conversion to the hydroxyurea increases its stability by a factor of 500. The hydroxyurea derivative strongly absorbs ultraviolet light (λmax. = 268 nm; am = 37,200) and is also electrochemically oxidized (Ep = +0.38 V vs. Ag/AgCl) at a glassy carbon surface. The HPLC eluent is therefore monitore both spectrophotometrically (at 254 nm) and amperomatrically (at 0.50 V at a glassy carbon anode). Optical detection offers a sensitivity of 9· 10—M while electromechanical detection affords a sensitivity limit of 1· 10—M." @default.
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- W2017684449 date "1980-01-01" @default.
- W2017684449 modified "2023-09-23" @default.
- W2017684449 title "Conversion of arylhydroxylamines to electrochemically-active derivatives suitable for high-performance liquid chromatographic analysis with amperometric detection" @default.
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- W2017684449 doi "https://doi.org/10.1016/s0021-9673(00)88426-5" @default.
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