FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017686370> ?p ?o ?g. }

• W2017686370 endingPage "1192" @default.
• W2017686370 startingPage "1171" @default.
• W2017686370 abstract "The linear organization of collagen fibers in tendons results in optimal stiffness and strength at low strains under tensile load. However, this organization makes repairing ruptured or lacerated tendons extremely difficult. Current suturing techniques to join split ends of tendons, while providing sufficient mechanical strength to prevent gapping, are inadequate to carry normal loads. Immobilization protocols necessary to restore tendon congruity result in scar formation at the repair site and peripheral adhesions that limit excursion. These problems are reviewed to emphasize the need for novel approaches to tendon repair, one of which is the development of biomimetic tendons. The objective of the empirical work described here was to produce biologically-based, biocompatible tendon replacements with appropriate mechanical properties to enable immediate mobilization following surgical repair. Nor-dihydroguaiaretic acid (NDGA), a di-catechol from creosote bush, caused a dose dependent increase in the material properties of reconstituted collagen fibers, achieving a 100-fold increase in strength and stiffness over untreated fibers. The maximum tensile strength of the optimized NDGA treated fibers averaged 90 MPa; the elastic modulus of these fibers averaged 580 MPa. These properties were independent of strain rates ranging from 0.60 to 600 mm/min. Fatigue tests established that neither strength nor stiffness were affected after 80 k cycles at 5% strain. Treated fibers were not cytotoxic to tendon fibroblasts. Fibroblasts attached and proliferated on NDGA treated collagen normally. NDGA-fibers did not elicit a foreign body response nor did they stimulate an immune reaction during six weeks in vivo. The fibers survived 6 weeks with little evidence of fragmentation or degradation. The polymerization scheme described here produces a fiber-reinforced NDGA-polymer with mechanical properties approaching an elastic solid. The strength, stiffness and fatigue properties of the NDGA-treated fibers are comparable to those of tendon. These fibers are biocompatible with tendon fibroblasts and elicit little rejection or antigenic response in vivo. These results indicate that NDGA polymerization may provide a viable approach for producing collagenous materials that can be used to bridge gaps in ruptured or lacerated tendons. The tendon-like properties of the NDGA-fiber would allow early mobilization after surgical repair. We predict that timely loading of parted tendons joined by this novel biomaterial will enhance mechanically driven production of neo-tendon by the colonizing fibroblasts and result in superior repair and rapid return to normal properties." @default.
• W2017686370 created "2016-06-24" @default.
• W2017686370 creator A5046932964 @default.
• W2017686370 date "2002-12-01" @default.
• W2017686370 modified "2023-09-23" @default.
• W2017686370 title "Biomimetic approaches to tendon repair" @default.
• W2017686370 cites W156099281 @default.
• W2017686370 cites W1598501399 @default.
• W2017686370 cites W1601068592 @default.
• W2017686370 cites W1864154040 @default.
• W2017686370 cites W1940226375 @default.
• W2017686370 cites W1967643924 @default.
• W2017686370 cites W1968329347 @default.
• W2017686370 cites W1970596483 @default.
• W2017686370 cites W1971959577 @default.
• W2017686370 cites W1973722837 @default.
• W2017686370 cites W1977013090 @default.
• W2017686370 cites W1980778886 @default.
• W2017686370 cites W1983668576 @default.
• W2017686370 cites W1986002557 @default.
• W2017686370 cites W1986300999 @default.
• W2017686370 cites W1986831882 @default.
• W2017686370 cites W1987036123 @default.
• W2017686370 cites W1987372502 @default.
• W2017686370 cites W1988245710 @default.
• W2017686370 cites W1988983513 @default.
• W2017686370 cites W1991041702 @default.
• W2017686370 cites W1991056861 @default.
• W2017686370 cites W1991210046 @default.
• W2017686370 cites W1993821272 @default.
• W2017686370 cites W1995728060 @default.
• W2017686370 cites W1997176346 @default.
• W2017686370 cites W1998630566 @default.
• W2017686370 cites W1999098362 @default.
• W2017686370 cites W1999422670 @default.
• W2017686370 cites W1999735810 @default.
• W2017686370 cites W2000400813 @default.
• W2017686370 cites W2001886226 @default.
• W2017686370 cites W2002843323 @default.
• W2017686370 cites W2008146465 @default.
• W2017686370 cites W2010739144 @default.
• W2017686370 cites W2011121154 @default.
• W2017686370 cites W2011575137 @default.
• W2017686370 cites W2012222854 @default.
• W2017686370 cites W2012650330 @default.
• W2017686370 cites W2016750430 @default.
• W2017686370 cites W2017500900 @default.
• W2017686370 cites W2017977587 @default.
• W2017686370 cites W2019660345 @default.
• W2017686370 cites W2019882629 @default.
• W2017686370 cites W2022318217 @default.
• W2017686370 cites W2024155339 @default.
• W2017686370 cites W2026412432 @default.
• W2017686370 cites W2028091323 @default.
• W2017686370 cites W2028509873 @default.
• W2017686370 cites W2029959490 @default.
• W2017686370 cites W2032189954 @default.
• W2017686370 cites W2032667301 @default.
• W2017686370 cites W2036647753 @default.
• W2017686370 cites W2036857231 @default.
• W2017686370 cites W2038579366 @default.
• W2017686370 cites W2038666128 @default.
• W2017686370 cites W2038820009 @default.
• W2017686370 cites W2038986364 @default.
• W2017686370 cites W2040818311 @default.
• W2017686370 cites W2040855374 @default.
• W2017686370 cites W2042808504 @default.
• W2017686370 cites W2043321717 @default.
• W2017686370 cites W2046842361 @default.
• W2017686370 cites W2048625931 @default.
• W2017686370 cites W2049798160 @default.
• W2017686370 cites W2051227473 @default.
• W2017686370 cites W2051565967 @default.
• W2017686370 cites W2052346791 @default.
• W2017686370 cites W2057374271 @default.
• W2017686370 cites W2059035066 @default.
• W2017686370 cites W2060787184 @default.
• W2017686370 cites W2061277200 @default.
• W2017686370 cites W2064714531 @default.
• W2017686370 cites W2066672104 @default.
• W2017686370 cites W2069010183 @default.
• W2017686370 cites W2069752380 @default.
• W2017686370 cites W2070515477 @default.
• W2017686370 cites W2074561607 @default.
• W2017686370 cites W2077696617 @default.
• W2017686370 cites W2078045644 @default.
• W2017686370 cites W2078345657 @default.
• W2017686370 cites W2079411521 @default.
• W2017686370 cites W2081755104 @default.
• W2017686370 cites W2081854922 @default.
• W2017686370 cites W2081882110 @default.
• W2017686370 cites W2086546072 @default.
• W2017686370 cites W2087565634 @default.
• W2017686370 cites W2088511719 @default.
• W2017686370 cites W2097415571 @default.
• W2017686370 cites W2098417217 @default.
• W2017686370 cites W2100303046 @default.
• W2017686370 cites W2106001254 @default.

• next