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- W2017686919 abstract "Background: Triple negative (TN) tumors are characterized by aggressive behavior and, the negative hormone receptor and HER2 status precludes the use of personalized therapies such as tamoxifen and trastuzumab. African American women have higher rates of both breast cancer mortality as well as TN breast tumors. What remains unknown is how much of these disparities can be attributed to molecular differences between populations. Methods: The Clinical Breast Care Project database was queried to identify African American women with triple negative, high-grade tumors. Caucasian women with highgrade TN tumors were then matched by age at diagnosis, tumor stage, size and lymph node status. RNA was isolated after laser microdissection of the tumor and hybridized to HG U133A 2.0 microarrays. Data was analyzed using Partek Genomics Suite. Results: Principal Component Analysis accurately clustered the triple negative specimens by ethnicity. Using a false-discovery rate (FDR) p-value Discussion: Despite matching of tumors by clinicopathological characteristics, molecular profiles of triple negative breast tumors differed between AAW and CW. These differences may serve as molecular targets for the development of novel prevention strategies and therapeutics to reduce the risk of developing and improve treatment of African American women with triple negative breast cancer. Citation Information: Cancer Epidemiol Biomarkers Prev 2011;20(10 Suppl):B31." @default.
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- W2017686919 date "2011-09-01" @default.
- W2017686919 modified "2023-09-25" @default.
- W2017686919 title "Abstract B31: Molecular signature discriminating triple-negative breast tumors between African American and Caucasian women" @default.
- W2017686919 doi "https://doi.org/10.1158/1055-9965.disp-11-b31" @default.
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