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- W2017687501 abstract "A neuronal determination factor was expressed in the developing melanocyte lineage to explore determinants of melanocyte development from the neural crest. Transgenic mice expressing the neurogenic bHLH factor MASH-1 from the dopachrome tautomerase (Dct) promoter were generated using a 3.2 kb fragment of Dct upstream regulatory sequence linked to a FLAG epitope-tagged version of the murine Mash1 gene. A single microphthalmic founder with a mosaic coat color phenotype produced non-pigmented, microphthalmic F1 progeny. The F1 progeny transmitted the transgene with approximately 50% frequency to F2 progeny that shared the phenotype. Analysis of the eye of transgenic embryos at E11.5 revealed the presence of a developing lens and neuroretinal layer. However, the structure corresponding anatomically to the location of the retinal pigmented epithelium (RPE) was supplanted by a non-pigmented layer, termed RPE-like layer, that is more than one cell thick. At E14.5, the neuroretina is elongated, and the RPE-like layer extends anterior to the lens, forming a single continuous structure when examined in transverse sections. The ocular and coat color phenotypes of the Dct::Mash1 transgenic line demonstrate that expression of Mash1 in pigment cell precursors alters the development or differentiation of both non-neural crest-derived cells of the RPE and neural crest-derived melanocytes. These alterations result in the failure of proper eye development and in a dominantly inherited mutant coat color phenotype, respectively." @default.
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- W2017687501 date "2000-08-01" @default.
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- W2017687501 title "Microphthalmia and Loss of Coat Pigmentation from Transgenic Expression of a Neurogenic Factor in Pigment Cell Precursors." @default.
- W2017687501 doi "https://doi.org/10.1046/j.1523-1747.2000.00abs-3.x" @default.
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