FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017691305> ?p ?o ?g. }

• W2017691305 endingPage "2869" @default.
• W2017691305 startingPage "2865" @default.
• W2017691305 abstract "Phorbol esters are potent inducers of macrophage-like differentiation in the HL-60 promyelocytic leukemia cell line. The sequence of events by which they bring about this transition is poorly understood. However, it is known that phorbol esters bind to the surface membrane of HL-60 cells and to various other cells as well. Our studies were directed toward determining the biologic importance of this membrane association. [3H]Phorbol dibutyrate (PBu2) was specifically bound by HL-60 cells with a Kd of 23 nM and with 1.9 X 10(5) binding sites for [3H]PBu2 per cell. There was no internalization of bound [3H]PBu2. Specific binding was fully reversible upon washing in fresh medium, and [3H]PBu2 added thereafter bound normally to its receptor. Within 10 min of binding, PBu2 stimulated [14C]choline incorporation into phosphatidylcholine, with a rapid return to normal upon removal of the PBu2. Membrane-bound PBu2 progressively inhibited DNA synthesis, with 70% inhibition by 8 hr. This process was interrupted if the PBu2 was removed, and little recovery of DNA synthesis occurred in previously inhibited cells. Between 8 and 16 hr, PBu2 induced adherence of cells to plastic, but only in those cells in which phosphatidylcholine synthesis was stimulated, and this process was also interrupted if PBu2 was removed prior to 16 hr. Similarly, nonspecific esterase, which develops after 72 hr of incubation, was induced in cells exposed to PBu2 for the initial 16 hr but not in cells exposed for 5 hr. These studies demonstrate that phorbol esters exert their effects while retained at the cell surface. Inhibition of cell growth and the acquisition of surface and enzymatic properties that characterize macrophages are separable events, each of which proceeds through a receptor-mediated, transmembrane process. The stimulation of phosphatidylcholine synthesis appears to be a part of that process." @default.
• W2017691305 created "2016-06-24" @default.
• W2017691305 creator A5015009401 @default.
• W2017691305 creator A5052482376 @default.
• W2017691305 creator A5073171800 @default.
• W2017691305 date "1982-05-01" @default.
• W2017691305 modified "2023-09-26" @default.
• W2017691305 title "Phorbol ester induction of leukemic cell differentiation is a membrane-mediated process." @default.
• W2017691305 cites W1490807285 @default.
• W2017691305 cites W1522272844 @default.
• W2017691305 cites W1553067174 @default.
• W2017691305 cites W1900801434 @default.
• W2017691305 cites W1965704924 @default.
• W2017691305 cites W1965909772 @default.
• W2017691305 cites W1973829394 @default.
• W2017691305 cites W1974170868 @default.
• W2017691305 cites W1979704489 @default.
• W2017691305 cites W1981589031 @default.
• W2017691305 cites W1985700987 @default.
• W2017691305 cites W1989540637 @default.
• W2017691305 cites W1999689481 @default.
• W2017691305 cites W2014520088 @default.
• W2017691305 cites W2019705381 @default.
• W2017691305 cites W2028692741 @default.
• W2017691305 cites W2039014436 @default.
• W2017691305 cites W2054697635 @default.
• W2017691305 cites W2058901530 @default.
• W2017691305 cites W2066960428 @default.
• W2017691305 cites W2077494676 @default.
• W2017691305 cites W2100462945 @default.
• W2017691305 cites W210488995 @default.
• W2017691305 cites W2141083396 @default.
• W2017691305 cites W2147062815 @default.
• W2017691305 cites W2329211716 @default.
• W2017691305 cites W2346564971 @default.
• W2017691305 cites W2464462886 @default.
• W2017691305 cites W2468992926 @default.
• W2017691305 doi "https://doi.org/10.1073/pnas.79.9.2865" @default.
• W2017691305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/346307" @default.
• W2017691305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6953435" @default.
• W2017691305 hasPublicationYear "1982" @default.
• W2017691305 type Work @default.
• W2017691305 sameAs 2017691305 @default.
• W2017691305 citedByCount "82" @default.
• W2017691305 crossrefType "journal-article" @default.
• W2017691305 hasAuthorship W2017691305A5015009401 @default.
• W2017691305 hasAuthorship W2017691305A5052482376 @default.
• W2017691305 hasAuthorship W2017691305A5073171800 @default.
• W2017691305 hasBestOaLocation W20176913052 @default.
• W2017691305 hasConcept C139770010 @default.
• W2017691305 hasConcept C1491633281 @default.
• W2017691305 hasConcept C153911025 @default.
• W2017691305 hasConcept C170493617 @default.
• W2017691305 hasConcept C181199279 @default.
• W2017691305 hasConcept C185592680 @default.
• W2017691305 hasConcept C195794163 @default.
• W2017691305 hasConcept C2776330855 @default.
• W2017691305 hasConcept C2778106830 @default.
• W2017691305 hasConcept C2778918659 @default.
• W2017691305 hasConcept C2780043322 @default.
• W2017691305 hasConcept C41625074 @default.
• W2017691305 hasConcept C54355233 @default.
• W2017691305 hasConcept C552990157 @default.
• W2017691305 hasConcept C55493867 @default.
• W2017691305 hasConcept C64241487 @default.
• W2017691305 hasConcept C81885089 @default.
• W2017691305 hasConcept C86803240 @default.
• W2017691305 hasConcept C95444343 @default.
• W2017691305 hasConceptScore W2017691305C139770010 @default.
• W2017691305 hasConceptScore W2017691305C1491633281 @default.
• W2017691305 hasConceptScore W2017691305C153911025 @default.
• W2017691305 hasConceptScore W2017691305C170493617 @default.
• W2017691305 hasConceptScore W2017691305C181199279 @default.
• W2017691305 hasConceptScore W2017691305C185592680 @default.
• W2017691305 hasConceptScore W2017691305C195794163 @default.
• W2017691305 hasConceptScore W2017691305C2776330855 @default.
• W2017691305 hasConceptScore W2017691305C2778106830 @default.
• W2017691305 hasConceptScore W2017691305C2778918659 @default.
• W2017691305 hasConceptScore W2017691305C2780043322 @default.
• W2017691305 hasConceptScore W2017691305C41625074 @default.
• W2017691305 hasConceptScore W2017691305C54355233 @default.
• W2017691305 hasConceptScore W2017691305C552990157 @default.
• W2017691305 hasConceptScore W2017691305C55493867 @default.
• W2017691305 hasConceptScore W2017691305C64241487 @default.
• W2017691305 hasConceptScore W2017691305C81885089 @default.
• W2017691305 hasConceptScore W2017691305C86803240 @default.
• W2017691305 hasConceptScore W2017691305C95444343 @default.
• W2017691305 hasIssue "9" @default.
• W2017691305 hasLocation W20176913051 @default.
• W2017691305 hasLocation W20176913052 @default.
• W2017691305 hasLocation W20176913053 @default.
• W2017691305 hasLocation W20176913054 @default.
• W2017691305 hasOpenAccess W2017691305 @default.
• W2017691305 hasPrimaryLocation W20176913051 @default.
• W2017691305 hasRelatedWork W1557687412 @default.
• W2017691305 hasRelatedWork W2014534222 @default.
• W2017691305 hasRelatedWork W2017691305 @default.
• W2017691305 hasRelatedWork W2038177093 @default.

• next