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• W2017691917 abstract "One of the major challenges in stem cell research is to decipher the controlling mechanisms/genes of stem cell homeostasis. Through an RNAi mediated genetic screen of living animals, we identified an evolutionarily conserved histone acetyltransferase Atac2 as a novel regulator of Drosophila intestinal stem cells (ISCs). Expression of Atac2-RNAi or a dominant negative allele of Atac2 generated more ISCs, while excessive Atac2 or a histone deacetylase inhibitor promoted ISC differentiation without affecting ISC survival or lineage specification. These findings extend our knowledge of epigenetic mechanisms in stem cell regulation." @default.
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• W2017691917 date "2013-03-25" @default.
• W2017691917 modified "2023-10-18" @default.
• W2017691917 title "Identification of a histone acetyltransferase as a novel regulator of<i>Drosophila</i>intestinal stem cells" @default.
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• W2017691917 doi "https://doi.org/10.1016/j.febslet.2013.03.013" @default.
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