FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017692207> ?p ?o ?g. }

• W2017692207 endingPage "35" @default.
• W2017692207 startingPage "28" @default.
• W2017692207 abstract "The Class A family of guanine nucleotide-binding protein (G protein)-coupled receptors that includes receptors for motilin, ghrelin, and growth hormone secretagogue (GHS) has substantial potential importance as drug targets. Understanding of the molecular basis of hormone binding and receptor activation should provide insights helpful in the development of such drugs. We previously reported that Cys residues and the perimembranous residues in the extracellular loops and amino-terminal tail of the motilin receptor are critical for peptide ligand, motilin, binding and biological activity. In the current work, we focused on the predicted extracellular domains of the human GHS receptor 1a, and identified functionally important residues by using sequential deletions ranging from one to twelve amino acid residues and site-directed replacement mutagenesis approach. Each construct was transiently expressed in COS cells, and characterized for ghrelin- and growth hormone releasing peptide (GHRP)-6-stimulated intracellular calcium responses and ghrelin radioligand binding. Cys residues in positions 116 and 198 in the first and second extracellular loops and the perimembranous Glu¹⁸⁷ residue in the second extracellular loop were critical for ghrelin and GHRP-6 biological activity. These results suggest that Cys residues in the extracellular domains in this family of Class A G protein-coupled receptor is likely involved in the highly conserved and functionally important disulfide bond, and that the perimembranous residues contribute peptide ligand binding and signaling." @default.
• W2017692207 created "2016-06-24" @default.
• W2017692207 creator A5012636443 @default.
• W2017692207 creator A5035134420 @default.
• W2017692207 creator A5037424440 @default.
• W2017692207 creator A5066341447 @default.
• W2017692207 creator A5075913064 @default.
• W2017692207 creator A5086396689 @default.
• W2017692207 creator A5087484635 @default.
• W2017692207 date "2011-01-01" @default.
• W2017692207 modified "2023-09-25" @default.
• W2017692207 title "Mutational analysis of predicted extracellular domains of human growth hormone secretagogue receptor 1a" @default.
• W2017692207 cites W1964081706 @default.
• W2017692207 cites W1978416618 @default.
• W2017692207 cites W1981243084 @default.
• W2017692207 cites W1987386824 @default.
• W2017692207 cites W1995734405 @default.
• W2017692207 cites W2000867428 @default.
• W2017692207 cites W2006842912 @default.
• W2017692207 cites W2029938638 @default.
• W2017692207 cites W2035600501 @default.
• W2017692207 cites W2038202097 @default.
• W2017692207 cites W2043813981 @default.
• W2017692207 cites W2049105371 @default.
• W2017692207 cites W2051058773 @default.
• W2017692207 cites W2053680491 @default.
• W2017692207 cites W2081246610 @default.
• W2017692207 cites W2089969405 @default.
• W2017692207 cites W2108122320 @default.
• W2017692207 cites W2111536564 @default.
• W2017692207 cites W2118304925 @default.
• W2017692207 cites W2141260882 @default.
• W2017692207 cites W2141793702 @default.
• W2017692207 cites W2144623624 @default.
• W2017692207 cites W2152643580 @default.
• W2017692207 cites W2152988390 @default.
• W2017692207 cites W2153940484 @default.
• W2017692207 cites W2161035962 @default.
• W2017692207 cites W2163456630 @default.
• W2017692207 cites W2163865122 @default.
• W2017692207 cites W2168988227 @default.
• W2017692207 cites W2121124188 @default.
• W2017692207 doi "https://doi.org/10.1016/j.regpep.2010.08.002" @default.
• W2017692207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20727371" @default.
• W2017692207 hasPublicationYear "2011" @default.
• W2017692207 type Work @default.
• W2017692207 sameAs 2017692207 @default.
• W2017692207 citedByCount "9" @default.
• W2017692207 countsByYear W20176922072012 @default.
• W2017692207 countsByYear W20176922072013 @default.
• W2017692207 countsByYear W20176922072014 @default.
• W2017692207 countsByYear W20176922072019 @default.
• W2017692207 countsByYear W20176922072022 @default.
• W2017692207 countsByYear W20176922072023 @default.
• W2017692207 crossrefType "journal-article" @default.
• W2017692207 hasAuthorship W2017692207A5012636443 @default.
• W2017692207 hasAuthorship W2017692207A5035134420 @default.
• W2017692207 hasAuthorship W2017692207A5037424440 @default.
• W2017692207 hasAuthorship W2017692207A5066341447 @default.
• W2017692207 hasAuthorship W2017692207A5075913064 @default.
• W2017692207 hasAuthorship W2017692207A5086396689 @default.
• W2017692207 hasAuthorship W2017692207A5087484635 @default.
• W2017692207 hasConcept C131793682 @default.
• W2017692207 hasConcept C134018914 @default.
• W2017692207 hasConcept C135285700 @default.
• W2017692207 hasConcept C170493617 @default.
• W2017692207 hasConcept C185592680 @default.
• W2017692207 hasConcept C2779281246 @default.
• W2017692207 hasConcept C2779357093 @default.
• W2017692207 hasConcept C28406088 @default.
• W2017692207 hasConcept C55493867 @default.
• W2017692207 hasConcept C86803240 @default.
• W2017692207 hasConceptScore W2017692207C131793682 @default.
• W2017692207 hasConceptScore W2017692207C134018914 @default.
• W2017692207 hasConceptScore W2017692207C135285700 @default.
• W2017692207 hasConceptScore W2017692207C170493617 @default.
• W2017692207 hasConceptScore W2017692207C185592680 @default.
• W2017692207 hasConceptScore W2017692207C2779281246 @default.
• W2017692207 hasConceptScore W2017692207C2779357093 @default.
• W2017692207 hasConceptScore W2017692207C28406088 @default.
• W2017692207 hasConceptScore W2017692207C55493867 @default.
• W2017692207 hasConceptScore W2017692207C86803240 @default.
• W2017692207 hasFunder F4320320912 @default.
• W2017692207 hasIssue "1-3" @default.
• W2017692207 hasLocation W20176922071 @default.
• W2017692207 hasLocation W20176922072 @default.
• W2017692207 hasOpenAccess W2017692207 @default.
• W2017692207 hasPrimaryLocation W20176922071 @default.
• W2017692207 hasRelatedWork W1549143183 @default.
• W2017692207 hasRelatedWork W1969888489 @default.
• W2017692207 hasRelatedWork W1982566926 @default.
• W2017692207 hasRelatedWork W2055347371 @default.
• W2017692207 hasRelatedWork W2058549283 @default.
• W2017692207 hasRelatedWork W2062311257 @default.
• W2017692207 hasRelatedWork W2080578569 @default.
• W2017692207 hasRelatedWork W2084474801 @default.
• W2017692207 hasRelatedWork W2313644042 @default.
• W2017692207 hasRelatedWork W2396263754 @default.

• next