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• W2017693171 abstract "The transport of the biogenic amines, 5-hydroxytryptamine and norepinephrine, was studied using isolated nerve endings (synaptosomes) prepared from rat and rabbit brains. The transport was absolutely dependent upon Na+, but maximum transport required K+. In the absence of K+, transport increased with increasing [Na+] up to about 75 mM, then decreased. High [K+] decreased transport in the presence of Na+. In the absence of K+, a lapse of time preceded the blockade of transport. Moreover, preliminary incubation of synaptosomes in K+-free media containing 150 mM Na+ blocked initial transport more than media containing 50 mM Na+. It is concluded that K+-lack blocks transport as a result of changes in transmembrane ion gradients secondary to the inhibition of (Na+ + K+)-ATPase. K+-lack slightly increased the efflux of stored norepinephrine." @default.
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• W2017693171 date "1970-09-01" @default.
• W2017693171 modified "2023-10-18" @default.
• W2017693171 title "Mechanisms of biogenic amine transport and storage IV. Relationship between K+ and the Na+ requirement for transport and storage of 5-hydroxytryptamine and norepinephrine in synaptosomes" @default.
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• W2017693171 doi "https://doi.org/10.1016/0005-2736(70)90257-9" @default.
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