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- W2017693482 abstract "Known, densely substituted 3-amino-5,7,8-trichloro-6-hydroxycinnoline-4-carbonitrile was synthesized using a one pot synthetic protocol under base-mediated conditions in a polar medium. Condensation of excess malononitrile with chloranil in ethanol at reflux gave quinone methide—2-(2,4,5-trichloro-3-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)malononitrile which was isolated as the triethylamine salt. This represents an atom efficient, simple, and effective procedure for the preparation of a highly substituted cinnolines that may serve as relay materials for antimalarial prototypes." @default.
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- W2017693482 title "Structural similarity between febrifugine and chloroquine" @default.
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