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• W2017693744 abstract "Background/Aim: CD155 is expressed in many types of human cells and has diverse functions. We herein evaluated the cli n i cal importance of CD155 in pancreatic cancer. Materials and Methods: We investigated CD155 expression in 134 patients with pancreatic cancer, and evaluated the correlations of CD155 with prognosis, tumor immunity and angiogenesis. Furthermore, CD155 functions were examined. Results: CD155 expression was abundant in pancreatic cancer tissues. Patients with high CD155 expression had poorer postoperative prognosis than those with low expression. Multivariate analysis indicated that CD155 expression had a significant independent prognostic value. Tumor CD155 expression inversely correlated with the presence of tumor-infiltrating lymphocytes. Furthermore, it significantly positively correlated with vascular endothelial growth factor expres sion and intra tumoral microvessel density. In addition, silencing of CD155 inhibited proliferation, and induced cell-cycle arrest at G₂/M phase in pancreatic cancer cells. Conclusion: CD155 may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer and may be a therapeutic target for this intractable malignancy." @default.
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• W2017693744 date "2003-05-10" @default.
• W2017693744 modified "2023-09-27" @default.
• W2017693744 title "Association between antidepressant prescribing and suicide in Australia, 1991-2000: trend analysis" @default.
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• W2017693744 doi "https://doi.org/10.1136/bmj.326.7397.1008" @default.
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