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- W2017694773 abstract "Aims: To compare empiric antibiotics with the sensitivities of organisms causing acquired septicaemia in infants in a tertiary neonatal unit Methods: We performed a retrospective audit of culture-positive septicaemia in the Grantley Stable Neonatal Unit between January 2005 and December 2009. Cases were identified using the unit's database. Relevant data were extracted from the database or, where necessary, by reviewing patient files. Results: During the study period there were 7572 admissions, with 120 episodes of septicaemia in 109 patients. The most common organisms isolated were enteric Gram-negative bacilli (n=34), coagulasenegative Staphylococcus (CONS) species (n=31) and Staphylococcus aureus (n=24). Sufficient data for analysis were available for 116 episodes in 105 patients. Empiric antibiotics prescribed most frequently were ampicillin, cefotaxime, gentamicin and metronidazole. Number of antibiotics used empirically in each episode ranged from 2 to 4. The most commonly used antibiotic regimen was ampicillin and cefotaxime. The chosen regimen included antibiotic/s that matched the reported sensitivities in 56/116 (48%) episodes. Of the 60 cases where the reported sensitivities did not include the empiric antibiotics, the regimen nevertheless provided partial cover in 23. In 19 of the remaining 37 cases, the infecting organism was CONS. Conclusions: Empiric antibiotic regimens provided adequate or partial cover against septicaemiacausing organisms in two-thirds of cases. In a significant minority the regimen was inadequate. However, half of these were caused by CONS, which is known to be less virulent than other septicaemia-causing organisms. Broader empiric antibiotic cover may be impractical but knowledge of prior colonising organisms may help." @default.
- W2017694773 created "2016-06-24" @default.
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- W2017694773 date "2010-11-01" @default.
- W2017694773 modified "2023-10-18" @default.
- W2017694773 title "521 A Comparison of Empiric Antibiotics and Sensitivities of Organisms Causing Acquired Neonatal Septicaemia" @default.
- W2017694773 doi "https://doi.org/10.1203/00006450-201011001-00521" @default.
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