FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017696307> ?p ?o ?g. }

• W2017696307 endingPage "698" @default.
• W2017696307 startingPage "685" @default.
• W2017696307 abstract "Cytotactin, an extracellular glycoprotein found in neural and nonneural tissues, influences a variety of cellular phenomena, particularly cell adhesion and cell migration. Northern and Western blot analysis and in situ hybridization were used to determine localization of alternatively spliced forms of cytotactin in neural and nonneural tissues using a probe (CT) that detected all forms of cytotactin mRNA, and one (VbVc) that detected two of the differentially spliced repeats homologous to the type III repeats of fibronectin. In the brain, the levels of mRNA and protein increased from E8 through E15 and then gradually decreased until they were barely detectable by P3. Among the three cytotactin mRNAs (7.2, 6.6, and 6.4 kb) detected in the brain, the VbVc probe hybridized only to the 7.2-kb message. In isolated cerebella, the 220-kD polypeptide and 7.2-kb mRNA were the only cytotactin species present at hatching, indicating that the 220-kD polypeptide is encoded by the 7.2-kb message that contains the VbVc alternatively spliced insert. In situ hybridization showed cytotactin mRNA in glia and glial precursors in the ventricular zone throughout the central nervous system. In all regions of the nervous system, cytotactin mRNAs were more transient and more localized than the polypeptides. For example, in the radial glia, cytotactin mRNA was observed in the soma whereas the protein was present externally along the glial fibers. In the telencephalon, cytotactin mRNAs were found in a narrow band at the edge of a larger region in which the protein was wide-spread. Hybridization with the VbVc probe generally overlapped that of the CT probe in the spinal cord and cerebellum, consistent with the results of Northern blot analysis. In contrast, in the outermost tectal layers, differential hybridization was observed with the two probes. In nonneural tissues, hybridization with the CT probe, but not the VbVc probe, was detected in chondroblasts, tendinous tissues, and certain mesenchymal cells in the lung. In contrast, hybridization with both probes was observed in smooth muscle and lung epithelium. Both epithelium and mesenchyme expressed cytotactin mRNA in varying combinations: in the choroid plexus, only epithelial cells expressed cytotactin mRNA; in kidney, only mesenchymal cells; and in the lung, both of these cell types contained cytotactin mRNA. These spatiotemporal changes during development suggest that the synthesis of the various alternatively spliced cytotactin mRNAs is responsive to tissue-specific local signals and prompt a search for functional differences in the various molecular forms of the protein." @default.
• W2017696307 created "2016-06-24" @default.
• W2017696307 creator A5015861706 @default.
• W2017696307 creator A5022425980 @default.
• W2017696307 creator A5035814482 @default.
• W2017696307 creator A5036455593 @default.
• W2017696307 creator A5047299361 @default.
• W2017696307 date "1990-08-01" @default.
• W2017696307 modified "2023-09-24" @default.
• W2017696307 title "Localization during development of alternatively spliced forms of cytotactin mRNA by in situ hybridization." @default.
• W2017696307 cites W1493066666 @default.
• W2017696307 cites W1531518952 @default.
• W2017696307 cites W1852165254 @default.
• W2017696307 cites W1948811175 @default.
• W2017696307 cites W194897549 @default.
• W2017696307 cites W1962262283 @default.
• W2017696307 cites W1966447656 @default.
• W2017696307 cites W1967421456 @default.
• W2017696307 cites W1969742740 @default.
• W2017696307 cites W1988297300 @default.
• W2017696307 cites W1990387345 @default.
• W2017696307 cites W1998031852 @default.
• W2017696307 cites W2005432934 @default.
• W2017696307 cites W2012447063 @default.
• W2017696307 cites W2013381560 @default.
• W2017696307 cites W2014195384 @default.
• W2017696307 cites W2014530663 @default.
• W2017696307 cites W2014867114 @default.
• W2017696307 cites W2018289835 @default.
• W2017696307 cites W2023227526 @default.
• W2017696307 cites W2024019011 @default.
• W2017696307 cites W2026798810 @default.
• W2017696307 cites W2028682121 @default.
• W2017696307 cites W2039729151 @default.
• W2017696307 cites W2055006843 @default.
• W2017696307 cites W2056205231 @default.
• W2017696307 cites W2059375645 @default.
• W2017696307 cites W2060062273 @default.
• W2017696307 cites W2061829345 @default.
• W2017696307 cites W2064199615 @default.
• W2017696307 cites W2066170881 @default.
• W2017696307 cites W2069007382 @default.
• W2017696307 cites W2074371746 @default.
• W2017696307 cites W2076097077 @default.
• W2017696307 cites W2081027942 @default.
• W2017696307 cites W2083219693 @default.
• W2017696307 cites W2100837269 @default.
• W2017696307 cites W2106316593 @default.
• W2017696307 cites W2112300132 @default.
• W2017696307 cites W2114569219 @default.
• W2017696307 cites W2119074990 @default.
• W2017696307 cites W2124093417 @default.
• W2017696307 cites W2128635872 @default.
• W2017696307 cites W2136476458 @default.
• W2017696307 cites W2169318446 @default.
• W2017696307 cites W2169830664 @default.
• W2017696307 cites W2170422576 @default.
• W2017696307 cites W2226557524 @default.
• W2017696307 cites W2398689627 @default.
• W2017696307 cites W291184357 @default.
• W2017696307 doi "https://doi.org/10.1083/jcb.111.2.685" @default.
• W2017696307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2116179" @default.
• W2017696307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1696267" @default.
• W2017696307 hasPublicationYear "1990" @default.
• W2017696307 type Work @default.
• W2017696307 sameAs 2017696307 @default.
• W2017696307 citedByCount "169" @default.
• W2017696307 countsByYear W20176963072012 @default.
• W2017696307 countsByYear W20176963072014 @default.
• W2017696307 countsByYear W20176963072016 @default.
• W2017696307 countsByYear W20176963072018 @default.
• W2017696307 countsByYear W20176963072020 @default.
• W2017696307 crossrefType "journal-article" @default.
• W2017696307 hasAuthorship W2017696307A5015861706 @default.
• W2017696307 hasAuthorship W2017696307A5022425980 @default.
• W2017696307 hasAuthorship W2017696307A5035814482 @default.
• W2017696307 hasAuthorship W2017696307A5036455593 @default.
• W2017696307 hasAuthorship W2017696307A5047299361 @default.
• W2017696307 hasBestOaLocation W20176963071 @default.
• W2017696307 hasConcept C104317684 @default.
• W2017696307 hasConcept C105580179 @default.
• W2017696307 hasConcept C153911025 @default.
• W2017696307 hasConcept C177707886 @default.
• W2017696307 hasConcept C54355233 @default.
• W2017696307 hasConcept C65666806 @default.
• W2017696307 hasConcept C67705224 @default.
• W2017696307 hasConcept C81439078 @default.
• W2017696307 hasConcept C86803240 @default.
• W2017696307 hasConcept C88478588 @default.
• W2017696307 hasConcept C95444343 @default.
• W2017696307 hasConceptScore W2017696307C104317684 @default.
• W2017696307 hasConceptScore W2017696307C105580179 @default.
• W2017696307 hasConceptScore W2017696307C153911025 @default.
• W2017696307 hasConceptScore W2017696307C177707886 @default.
• W2017696307 hasConceptScore W2017696307C54355233 @default.
• W2017696307 hasConceptScore W2017696307C65666806 @default.
• W2017696307 hasConceptScore W2017696307C67705224 @default.
• W2017696307 hasConceptScore W2017696307C81439078 @default.

• next