FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017697624> ?p ?o ?g. }

• W2017697624 endingPage "9077" @default.
• W2017697624 startingPage "9069" @default.
• W2017697624 abstract "ABSTRACT Biliary atresia (BA) is a devastating disease of childhood for which increasing evidence supports a viral component in pathogenesis. The murine model of BA is induced by perinatal infection with rhesus rotavirus (RRV) but not with other strains of rotavirus, such as TUCH. To determine which RRV gene segment(s) is responsible for pathogenesis, we used the RRV and TUCH strains to generate a complete set of single-gene reassortants. Eleven single-gene “loss-of-function” reassortants in which a TUCH gene replaced its RRV equivalent and 11 single-gene “gain-of-function” reassortants in which an RRV gene replaced its TUCH equivalent were generated. Newborn BALB/c mice were inoculated with the reassortants and were monitored for biliary obstruction and mortality. In vitro , the ability to bind to and replicate within cholangiocytes was analyzed. Infection of mice with the “loss-of-function” reassortant R T(VP4) , where gene 4 from TUCH was placed on an RRV background, eliminated the ability of RRV to cause murine BA. In a reciprocal fashion, the “gain-of-function” reassortant T R(VP4) resulted in murine BA with 88% mortality. Compared with those for RRV, R T(VP4) binding and titers in cholangiocytes were significantly attenuated, while T R(VP4) binding and titers were significantly increased over those for TUCH. Reassortants R T(VP3) and T R(VP3) induced an intermediate phenotype. RRV gene segment 4 plays a significant role in governing tropism for the cholangiocyte and the ability to induce murine BA. Gene segment 3 did not affect RRV infectivity in vitro but altered its in vivo effect." @default.
• W2017697624 created "2016-06-24" @default.
• W2017697624 creator A5003683006 @default.
• W2017697624 creator A5037518071 @default.
• W2017697624 creator A5038139240 @default.
• W2017697624 creator A5038614283 @default.
• W2017697624 creator A5043079359 @default.
• W2017697624 creator A5063551206 @default.
• W2017697624 creator A5064926369 @default.
• W2017697624 creator A5069889761 @default.
• W2017697624 creator A5076356039 @default.
• W2017697624 date "2011-09-01" @default.
• W2017697624 modified "2023-09-27" @default.
• W2017697624 title "The Rhesus Rotavirus Gene Encoding VP4 Is a Major Determinant in the Pathogenesis of Biliary Atresia in Newborn Mice" @default.
• W2017697624 cites W1548652080 @default.
• W2017697624 cites W1607977850 @default.
• W2017697624 cites W1930558155 @default.
• W2017697624 cites W1971283890 @default.
• W2017697624 cites W1975636001 @default.
• W2017697624 cites W1979378596 @default.
• W2017697624 cites W1979727917 @default.
• W2017697624 cites W1990745135 @default.
• W2017697624 cites W1990836208 @default.
• W2017697624 cites W1998851511 @default.
• W2017697624 cites W2006289424 @default.
• W2017697624 cites W2012284959 @default.
• W2017697624 cites W2030029322 @default.
• W2017697624 cites W2049449342 @default.
• W2017697624 cites W2057067536 @default.
• W2017697624 cites W2067317934 @default.
• W2017697624 cites W2074010058 @default.
• W2017697624 cites W2084269584 @default.
• W2017697624 cites W2090910360 @default.
• W2017697624 cites W2097175607 @default.
• W2017697624 cites W2101748842 @default.
• W2017697624 cites W2102568099 @default.
• W2017697624 cites W2109070106 @default.
• W2017697624 cites W2110552918 @default.
• W2017697624 cites W2114635621 @default.
• W2017697624 cites W2117742367 @default.
• W2017697624 cites W2121576794 @default.
• W2017697624 cites W2146458691 @default.
• W2017697624 cites W2151047157 @default.
• W2017697624 cites W2152068336 @default.
• W2017697624 cites W2159915045 @default.
• W2017697624 cites W2170126362 @default.
• W2017697624 cites W2171348589 @default.
• W2017697624 cites W2263715678 @default.
• W2017697624 cites W2318487150 @default.
• W2017697624 cites W2411190141 @default.
• W2017697624 cites W4210719727 @default.
• W2017697624 doi "https://doi.org/10.1128/jvi.02436-10" @default.
• W2017697624 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3165802" @default.
• W2017697624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21697466" @default.
• W2017697624 hasPublicationYear "2011" @default.
• W2017697624 type Work @default.
• W2017697624 sameAs 2017697624 @default.
• W2017697624 citedByCount "33" @default.
• W2017697624 countsByYear W20176976242012 @default.
• W2017697624 countsByYear W20176976242013 @default.
• W2017697624 countsByYear W20176976242014 @default.
• W2017697624 countsByYear W20176976242015 @default.
• W2017697624 countsByYear W20176976242016 @default.
• W2017697624 countsByYear W20176976242017 @default.
• W2017697624 countsByYear W20176976242018 @default.
• W2017697624 countsByYear W20176976242019 @default.
• W2017697624 countsByYear W20176976242020 @default.
• W2017697624 countsByYear W20176976242021 @default.
• W2017697624 countsByYear W20176976242022 @default.
• W2017697624 countsByYear W20176976242023 @default.
• W2017697624 crossrefType "journal-article" @default.
• W2017697624 hasAuthorship W2017697624A5003683006 @default.
• W2017697624 hasAuthorship W2017697624A5037518071 @default.
• W2017697624 hasAuthorship W2017697624A5038139240 @default.
• W2017697624 hasAuthorship W2017697624A5038614283 @default.
• W2017697624 hasAuthorship W2017697624A5043079359 @default.
• W2017697624 hasAuthorship W2017697624A5063551206 @default.
• W2017697624 hasAuthorship W2017697624A5064926369 @default.
• W2017697624 hasAuthorship W2017697624A5069889761 @default.
• W2017697624 hasAuthorship W2017697624A5076356039 @default.
• W2017697624 hasBestOaLocation W20176976241 @default.
• W2017697624 hasConcept C104317684 @default.
• W2017697624 hasConcept C126322002 @default.
• W2017697624 hasConcept C134018914 @default.
• W2017697624 hasConcept C159047783 @default.
• W2017697624 hasConcept C203014093 @default.
• W2017697624 hasConcept C2522874641 @default.
• W2017697624 hasConcept C2779243279 @default.
• W2017697624 hasConcept C2779609443 @default.
• W2017697624 hasConcept C2780186670 @default.
• W2017697624 hasConcept C2780942790 @default.
• W2017697624 hasConcept C2781367151 @default.
• W2017697624 hasConcept C2911091166 @default.
• W2017697624 hasConcept C35693153 @default.
• W2017697624 hasConcept C54355233 @default.
• W2017697624 hasConcept C71924100 @default.
• W2017697624 hasConcept C86803240 @default.
• W2017697624 hasConceptScore W2017697624C104317684 @default.

• next