Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017698288> ?p ?o ?g. }
- W2017698288 endingPage "1328" @default.
- W2017698288 startingPage "1319" @default.
- W2017698288 abstract "Sticholysin II (StnII) is a pore-forming protein (PFP) produced by the sea anemone Stichodactyla helianthus. We found out that StnII exists in a monomeric soluble state but forms tetramers in the presence of a lipidic interface. Both structures have been independently determined at 1.7 Å and 18 Å resolution, respectively, by using X-ray crystallography and electron microscopy of two-dimensional crystals. Besides, the structure of soluble StnII complexed with phosphocholine, determined at 2.4 Å resolution, reveals a phospholipid headgroup binding site, which is located in a region with an unusually high abundance of aromatic residues. Fitting of the atomic model into the electron microscopy density envelope suggests that while the β sandwich structure of the protein remains intact upon oligomerization, the N-terminal region and a flexible and highly basic loop undergo significant conformational changes. These results provide the structural basis for the membrane recognition step of actinoporins and unexpected insights into the oligomerization step." @default.
- W2017698288 created "2016-06-24" @default.
- W2017698288 creator A5021295789 @default.
- W2017698288 creator A5021320948 @default.
- W2017698288 creator A5025375215 @default.
- W2017698288 creator A5042064315 @default.
- W2017698288 creator A5073268079 @default.
- W2017698288 date "2003-11-01" @default.
- W2017698288 modified "2023-10-17" @default.
- W2017698288 title "Crystal and Electron Microscopy Structures of Sticholysin II Actinoporin Reveal Insights into the Mechanism of Membrane Pore Formation" @default.
- W2017698288 cites W1533620685 @default.
- W2017698288 cites W1623886086 @default.
- W2017698288 cites W1820852202 @default.
- W2017698288 cites W1965581896 @default.
- W2017698288 cites W1965642539 @default.
- W2017698288 cites W1980467950 @default.
- W2017698288 cites W1991146845 @default.
- W2017698288 cites W1993474057 @default.
- W2017698288 cites W1995017064 @default.
- W2017698288 cites W1996204565 @default.
- W2017698288 cites W1997256189 @default.
- W2017698288 cites W1997354932 @default.
- W2017698288 cites W2005040236 @default.
- W2017698288 cites W2005403912 @default.
- W2017698288 cites W2007107624 @default.
- W2017698288 cites W2013083986 @default.
- W2017698288 cites W2018532807 @default.
- W2017698288 cites W2026593599 @default.
- W2017698288 cites W2027549959 @default.
- W2017698288 cites W2029981682 @default.
- W2017698288 cites W2030683115 @default.
- W2017698288 cites W2038497192 @default.
- W2017698288 cites W2039617999 @default.
- W2017698288 cites W2047654176 @default.
- W2017698288 cites W2052589221 @default.
- W2017698288 cites W2054525948 @default.
- W2017698288 cites W2059890545 @default.
- W2017698288 cites W2072414401 @default.
- W2017698288 cites W2073718156 @default.
- W2017698288 cites W2078248419 @default.
- W2017698288 cites W2080476827 @default.
- W2017698288 cites W2080483188 @default.
- W2017698288 cites W2081846733 @default.
- W2017698288 cites W2085958374 @default.
- W2017698288 cites W2086639577 @default.
- W2017698288 cites W2090415455 @default.
- W2017698288 cites W2091969321 @default.
- W2017698288 cites W2093650342 @default.
- W2017698288 cites W2102902733 @default.
- W2017698288 cites W2104534420 @default.
- W2017698288 cites W2106315897 @default.
- W2017698288 cites W2109318635 @default.
- W2017698288 cites W2114283841 @default.
- W2017698288 cites W2122983835 @default.
- W2017698288 cites W2131909172 @default.
- W2017698288 cites W2164186503 @default.
- W2017698288 cites W4321429288 @default.
- W2017698288 doi "https://doi.org/10.1016/j.str.2003.09.019" @default.
- W2017698288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14604522" @default.
- W2017698288 hasPublicationYear "2003" @default.
- W2017698288 type Work @default.
- W2017698288 sameAs 2017698288 @default.
- W2017698288 citedByCount "211" @default.
- W2017698288 countsByYear W20176982882012 @default.
- W2017698288 countsByYear W20176982882013 @default.
- W2017698288 countsByYear W20176982882014 @default.
- W2017698288 countsByYear W20176982882015 @default.
- W2017698288 countsByYear W20176982882016 @default.
- W2017698288 countsByYear W20176982882017 @default.
- W2017698288 countsByYear W20176982882018 @default.
- W2017698288 countsByYear W20176982882019 @default.
- W2017698288 countsByYear W20176982882020 @default.
- W2017698288 countsByYear W20176982882021 @default.
- W2017698288 countsByYear W20176982882022 @default.
- W2017698288 countsByYear W20176982882023 @default.
- W2017698288 crossrefType "journal-article" @default.
- W2017698288 hasAuthorship W2017698288A5021295789 @default.
- W2017698288 hasAuthorship W2017698288A5021320948 @default.
- W2017698288 hasAuthorship W2017698288A5025375215 @default.
- W2017698288 hasAuthorship W2017698288A5042064315 @default.
- W2017698288 hasAuthorship W2017698288A5073268079 @default.
- W2017698288 hasBestOaLocation W20176982881 @default.
- W2017698288 hasConcept C115624301 @default.
- W2017698288 hasConcept C120665830 @default.
- W2017698288 hasConcept C121332964 @default.
- W2017698288 hasConcept C12554922 @default.
- W2017698288 hasConcept C138268822 @default.
- W2017698288 hasConcept C154945302 @default.
- W2017698288 hasConcept C166940927 @default.
- W2017698288 hasConcept C178790620 @default.
- W2017698288 hasConcept C185592680 @default.
- W2017698288 hasConcept C205076996 @default.
- W2017698288 hasConcept C20702342 @default.
- W2017698288 hasConcept C207114421 @default.
- W2017698288 hasConcept C41008148 @default.
- W2017698288 hasConcept C41625074 @default.
- W2017698288 hasConcept C47701112 @default.
- W2017698288 hasConcept C521977710 @default.