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- W2017704470 abstract "Reports have indicated that ,-radiation from tritium-labeled thymidine (H3TdR) incorporated into deoxyribonucleic acid (DNA) inhibits the survival and growth of tissue culture cells and ascites tumor cells (1-4); produces cytological effects in chick embryos (5); causes an increase in polyploid cells in the rat liver (6); damages spermatogonia (4, 7, 8); causes chromosome aberrations in plants (9-11), leukocytes (12), and regenerating rat liver cells (13); induces tumors in mice (14); and produces both lethality and mutations in mice (15) and bacteria (16-18). Except for the bacterial work, most of these studies are not quantitative in terlms of the amount of intranuclear incorporation measured either as the number of tritium disintegrations in the cell or as the dose in rads required to cause the effects observed. The object of the present study is (1) to determine the relationship between the number of visible chromosomal aberrations and the number of tritium disintegrations in the DNA, and (2) to compare the radiation dose delivered from H3TdR required to produce a certain amount of chromosomal damage with the radiation dose from chronic fAand y-radiation required to produce the same amount of damage." @default.
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- W2017704470 date "1965-02-01" @default.
- W2017704470 modified "2023-09-26" @default.
- W2017704470 title "Comparisons of Tritiated Thymidine, Tritiated Water, and Colbalt-60 Gamma Rays in Inducing Chromosomal Aberrations" @default.
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