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- W2017706022 abstract "Background: The most pathogenic bacterial microorganism associated with sore throat is Streptococcus pyogenes. The diagnosis is most often based on clinical management resulting to treatment failures and relapses. The main objective of this study was to assess the diagnostic value of a rapid streptococcal antigen detection test in patients with sore throat, using culture as reference test. Methods & Materials: From January to April 2011, a cross sectional study was carried out on 71 patients aged 3-72 years, presenting with signs and symptoms of sore throat at the University Teaching Hospital and the Central hospital of Yaounde in Cameroon. Two throat samples were collected per patient. One swab was used for the rapid diagnostic test (RADT) using a commercial antigen test (INSTALERT, Innovacon, Inc.CA 92121, USA) and the other swab was used for bacteriological analysis. Detection of streptococcal antigen was done using rapid antigen diagnostic test alongside culture in Columbia blood agar supplemented with nalidixic acid. Identification of streptococci was achieved by Lancefield agglutination. Antibiotic sensitivity was done by disc diffusion method on Mueller Hinton blood agar. Results: The most frequently clinical features in all patients was dysphagia, followed by fever. Only 21(29.6%) patients suffered from swollen cervical lymphnodes. Of the 71 samples collected, the RADT detected group A streptococcal antigens in 12 of 16 culture positive samples giving a sensitivity of 75%. This test was also positive in 2 specimens for group C and G Lancefield classification with a total of 53 true negatives. The specificity of the rapid test was 96%, with a positive predictive value of 85.7%, and a negative predictive value of 93%. The test was more sensitive (83.3%) for patients between the age group of 3 and 15years. Prevalence of Group A Streptococci was 22.5%. Two third of isolates (68%) were sensitive to penicillin G, while a high rate of resistance (64.3%) was observed with erythromycin. Conclusion: Rapid test have an additional value, however the sensitivity of the test studied was a little lower than expected, thus tests with a higher sensitivity are needed for accurate and reliable results for early diagnosis." @default.
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- W2017706022 date "2014-04-01" @default.
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- W2017706022 title "Diagnostic methods for group A Streptococcus associated with sore throat in Cameroon" @default.
- W2017706022 doi "https://doi.org/10.1016/j.ijid.2014.03.1200" @default.
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