Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017706664> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2017706664 endingPage "750" @default.
- W2017706664 startingPage "747" @default.
- W2017706664 abstract "A recent meta-analysis of 13 observational studies suggested reduced haemostatic efficacy during prophylaxis and shortened half-life of B-domain deleted factor VIII (BDD-rFVIII) as compared with full-length factor VIII (FL-FVIII). The meta-analysis included a multivariate model that took both dose and age into account. In addition, several assumptions and interpretations were required in order to conduct the meta-analysis. It is important to test the impact of such assumptions and interpretations through sensitivity analysis. In the published meta-analysis, results of several sensitivity analyses were described involving the effect of study design; heterogeneity of subjects in some studies; type of assay used for half-life determinations; and year of publication. In two subsequent brief reports, additional sensitivity analyses addressed choice of median-to-mean conversion factor over a wide range of scenarios and use of age at start of prophylaxis vs mean age during prophylaxis in the multivariate model. A recognized inherent difficulty in the meta-analysis of multiple published reports from similar studies is the possibility of some subject or data overlap. Therefore, the present communication details further sensitivity analyses encompassing assumptions regarding the possibility of subject duplication in a subgroup of subjects from one study and possible duplication of pharmacokinetic data from two smaller studies within the reports of two larger studies. All the sensitivity analyses support the main conclusions of the meta-analysis, namely, that BDD-rFVIII substantially increases the risk of breakthrough bleeding during prophylaxis, possibly at least partly because of shorter half-life than that of FL-FVIII." @default.
- W2017706664 created "2016-06-24" @default.
- W2017706664 creator A5007566100 @default.
- W2017706664 creator A5024806629 @default.
- W2017706664 creator A5030172187 @default.
- W2017706664 creator A5068229224 @default.
- W2017706664 date "2004-09-02" @default.
- W2017706664 modified "2023-10-15" @default.
- W2017706664 title "Meta-analytic evidence of increased breakthrough bleeding during prophylaxis with B-domain deleted factor VIII" @default.
- W2017706664 cites W1581671952 @default.
- W2017706664 cites W1598075387 @default.
- W2017706664 cites W1933904409 @default.
- W2017706664 cites W1981286429 @default.
- W2017706664 cites W1982605743 @default.
- W2017706664 cites W2005890977 @default.
- W2017706664 cites W2036386818 @default.
- W2017706664 cites W2047123804 @default.
- W2017706664 cites W2093662358 @default.
- W2017706664 cites W2168786919 @default.
- W2017706664 cites W56033953 @default.
- W2017706664 cites W61301347 @default.
- W2017706664 doi "https://doi.org/10.1111/j.1365-2516.2004.01034.x" @default.
- W2017706664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15569174" @default.
- W2017706664 hasPublicationYear "2004" @default.
- W2017706664 type Work @default.
- W2017706664 sameAs 2017706664 @default.
- W2017706664 citedByCount "13" @default.
- W2017706664 countsByYear W20177066642012 @default.
- W2017706664 countsByYear W20177066642013 @default.
- W2017706664 countsByYear W20177066642015 @default.
- W2017706664 countsByYear W20177066642016 @default.
- W2017706664 countsByYear W20177066642019 @default.
- W2017706664 crossrefType "journal-article" @default.
- W2017706664 hasAuthorship W2017706664A5007566100 @default.
- W2017706664 hasAuthorship W2017706664A5024806629 @default.
- W2017706664 hasAuthorship W2017706664A5030172187 @default.
- W2017706664 hasAuthorship W2017706664A5068229224 @default.
- W2017706664 hasConcept C105795698 @default.
- W2017706664 hasConcept C126322002 @default.
- W2017706664 hasConcept C161584116 @default.
- W2017706664 hasConcept C187960798 @default.
- W2017706664 hasConcept C23131810 @default.
- W2017706664 hasConcept C33923547 @default.
- W2017706664 hasConcept C38180746 @default.
- W2017706664 hasConcept C71924100 @default.
- W2017706664 hasConcept C95190672 @default.
- W2017706664 hasConceptScore W2017706664C105795698 @default.
- W2017706664 hasConceptScore W2017706664C126322002 @default.
- W2017706664 hasConceptScore W2017706664C161584116 @default.
- W2017706664 hasConceptScore W2017706664C187960798 @default.
- W2017706664 hasConceptScore W2017706664C23131810 @default.
- W2017706664 hasConceptScore W2017706664C33923547 @default.
- W2017706664 hasConceptScore W2017706664C38180746 @default.
- W2017706664 hasConceptScore W2017706664C71924100 @default.
- W2017706664 hasConceptScore W2017706664C95190672 @default.
- W2017706664 hasIssue "6" @default.
- W2017706664 hasLocation W20177066641 @default.
- W2017706664 hasLocation W20177066642 @default.
- W2017706664 hasOpenAccess W2017706664 @default.
- W2017706664 hasPrimaryLocation W20177066641 @default.
- W2017706664 hasRelatedWork W1570805059 @default.
- W2017706664 hasRelatedWork W1578824628 @default.
- W2017706664 hasRelatedWork W1974427739 @default.
- W2017706664 hasRelatedWork W1978174651 @default.
- W2017706664 hasRelatedWork W1978357124 @default.
- W2017706664 hasRelatedWork W2032728545 @default.
- W2017706664 hasRelatedWork W2036849593 @default.
- W2017706664 hasRelatedWork W2406638334 @default.
- W2017706664 hasRelatedWork W40745829 @default.
- W2017706664 hasRelatedWork W4318262572 @default.
- W2017706664 hasVolume "10" @default.
- W2017706664 isParatext "false" @default.
- W2017706664 isRetracted "false" @default.
- W2017706664 magId "2017706664" @default.
- W2017706664 workType "article" @default.