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• W2017706819 abstract "Two new triterpenoid saponins 1 and 2 were isolated from the methanol extract of the roots of Acanthophyllum gypsophiloides Regel . These saponins have quillaic acid or gypsogenin moieties as an aglycon, and both bear similar sets of two oligosaccharide chains, which are 3- O -linked to the triterpenoid part trisaccharide α-L-Ara p -(1→3)-[α-D-Gal p -(1→2)]-β-D-Glc p A and pentasaccharide β-D-Xyl p -(1→3)-β-D-Xyl p -(1→3)-α-L-Rha p -(1→2)-[β-D-Qui p -(1→4)]-β-D-Fuc p connected through an ester linkage to C-28. The structures of the obtained saponins were elucidated by a combination of mass spectrometry and 2D NMR spectroscopy. A study of acute toxicity, hemolytic, anti-inflammatory, immunoadjuvant and antifungal activity was carried out. Both saponins 1 and 2 were shown to exhibit immunoadjuvant properties within the vaccine composition with keyhole limpet hemocyanin-based immunogen. The availability of saponins 1 and 2 as individual pure compounds from the extract of the roots of A. gypsophiloides makes it a prospective source of immunoactive agents." @default.
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• W2017706819 date "2012-05-23" @default.
• W2017706819 modified "2023-10-06" @default.
• W2017706819 title "Triterpenoid saponins from the roots of<i>Acanthophyllum gypsophiloides</i>Regel" @default.
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• W2017706819 doi "https://doi.org/10.3762/bjoc.8.87" @default.
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