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• W2017728305 abstract "Many nutritional, hormonal, and environmental factors affect carcinogenesis and growth of established tumors in rodents. In some cases, these factors may either enhance or attenuate the neoplastic process. Recent experiments performed in our laboratory using tissue-isolated rat hepatoma 7288CTC in vivo or during perfusion in situ have demonstrated new interactions among four of these factors. Two agents, dietary linoleic acid (C18:2n6) and light at night, enhanced tumor growth, and two others, melatonin and n3 fatty acids, attenuated growth. Linoleic acid stimulated tumor growth because it is converted by hepatoma 7288CTC to the mitogen, 13-hydroxyoctadecadienoic acid (13-HODE). Melatonin, the neurohormone synthesized and secreted at night by the pineal gland, and dietary n3 fatty acids are potent antitumor agents. Both inhibited tumor linoleic acid uptake and 13-HODE formation. Artificial light, specifically light at night, increased tumor growth because it suppressed melatonin synthesis and enhanced 13-HODE formation. Melatonin and n3 fatty acids acted via similar or identical G(i) protein-coupled signal transduction pathways, except that melatonin receptors and putative n3 fatty acid receptors were used. The results link the four factors in a common mechanism and provide new insights into the roles of dietary n6 and n3 polyunsaturated fatty acid intake, light at night, and melatonin in cancer prevention in humans." @default.
• W2017728305 created "2016-06-24" @default.
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• W2017728305 date "2001-06-01" @default.
• W2017728305 modified "2023-10-13" @default.
• W2017728305 title "Polyunsaturated fatty acids, melatonin, and cancer prevention 1 1Abbreviations: 13-HODE, 13-hydroxyoctadecadienoic acid; NDGA, nordihydroguaiaretic acid; EGF, epidermal growth factor; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; 8-Br-cAMP, 8-bromo-cyclic adenosine monophosphate; FATP, fatty acid transport protein; cAMP, cyclic adenosine monophosphate; TGFα, tumor growth factor alpha; MAPK, mitogen-activated protein kinase; and FAT, fatty acid translocase." @default.
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• W2017728305 doi "https://doi.org/10.1016/s0006-2952(01)00634-7" @default.
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