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- W2017731404 abstract "To document pregnancy and long-term neurodevelopmental outcome and to determine the risk factors for death or neurodevelopmental impairment in monochorionic diamniotic (MCDA) twins. A prospective series of MCDA twin pregnancies recruited in the first trimester in 3 European countries (Jan2002-Oct2005). Information on conception, pregnancy and neonatal outcome was collected and surviving infants were assessed in the 3 study centers by the Bayley scales of infant development at 2 years of age. Death was defined as intra-uterine or neonatal death. Neurodevelopmental impairment (NDI) was defined as the occurrence of cerebral palsy (CP), a Bayley motor or mental score of < 2 SD, deafness or blindness. Multivariate logistic regression analysis was performed to identify the risk factors for death or NDI. 136 pregnancies (272 fetuses) were recruited. 11/136 (8%) were conceived by artificial reproductive technology (ART). 122/136 (90%) resulted in 2 survivors, 6/136 in 1 survivor (4%) and 8/136 without survivors (6%). Twin-to-twin transfusion syndrome (TTTS) occurred in 12/136 (9%) and discordant growth without TTTS in 24/136 (18%). Early-onset discordant growth diagnosed 20 weeks occurred in 16/136 pregnancies (12%). 230/250 surviving infants (92%) were assessed at a median age of 42 months. 22/230 (10%) infants had NDI; either CP (5; 2%); isolated motor delay (11; 5%); isolated mental delay (3; 1.5%); motor and mental delay (3; 1.5%). 166 infants resulted from pregnancies not complicated by TTTS, discordant growth, birth prior to 32 weeks or death of 1 twin. From these, 12 (7%) had NDI of whom 1 had CP (0.6%). Death or NDI occurred in 28/126 pregnancies (22%). TTTS (OR: 39; P < .0001), early-onset discordant growth (OR: 7; P < .001) and ART (OR: 5; P = .024) were significant risk factors for the occurrence of death or NDI. In this prospective cohort of MC twins, the mortality rate was 8% (22/272) and NDI occurred in 10% (22/230) of survivors. TTTS was the most important risk factor for death or neurodevelopmental impairment." @default.
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- W2017731404 date "2008-12-01" @default.
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- W2017731404 title "77: Pregnancy and long-term neurodevelopmental outcome in monochorionic diamniotic twin pregnancies: A multi-center prospective cohort study" @default.
- W2017731404 doi "https://doi.org/10.1016/j.ajog.2008.09.102" @default.
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