Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017733095> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2017733095 endingPage "601" @default.
- W2017733095 startingPage "591" @default.
- W2017733095 abstract "Mycophenolate mofetil (MPM), a new immunosuppressant, is a morpholinoethyl ester of mycophenolic acid (MPA). The enzymatic and non-enzymatic hydrolysis was studied in an artifical digestive fluid, rat plasma, and tissue homogenates. MPM was chemically stable in the artificial digestive fluid. In rat tissue homogenates and plasma, MPM was rapidly hydrolysed to MPA. The conversion rate of MPM to MPA in various rat tissue homogenates was in the order of liver > kidney > plasma > small-intestinal epithelial cells. After the intravenous injection of MPM at 16.7 mg kg−1, the terminal elimination half-life,-t1/2β, was 4.74 ± 0.33 (mean ± SD)h, and the area under the plasma concentration versus time curve, AUC, was 48.78 ± 6.01 μg h mL−1. After intraduodenal (ID) administration of MPM at 16.7 mg kg−1, t1/2β was 3.92 ± 1.05 h, and the AUC was 38.08 ± 8.30 μg h mL−1. The systemic availability of MPA after ID MPM dosing was 1.52 times higher than that after ID administration of MPA. This result supports the usefulness of MPM as an oral produrg of MPA as a new oral immunosuppressant." @default.
- W2017733095 created "2016-06-24" @default.
- W2017733095 creator A5031938815 @default.
- W2017733095 creator A5041858502 @default.
- W2017733095 creator A5052862047 @default.
- W2017733095 creator A5068527814 @default.
- W2017733095 creator A5077475492 @default.
- W2017733095 creator A5086059561 @default.
- W2017733095 creator A5087497175 @default.
- W2017733095 creator A5091761204 @default.
- W2017733095 date "1995-10-01" @default.
- W2017733095 modified "2023-10-11" @default.
- W2017733095 title "Stability and pharmacokinetic studies of a new immunosuppressant, mycophenolate mofetil (RS-61443), in rats" @default.
- W2017733095 cites W1489790705 @default.
- W2017733095 cites W1918694169 @default.
- W2017733095 cites W1995132602 @default.
- W2017733095 cites W1999435130 @default.
- W2017733095 cites W2000382292 @default.
- W2017733095 cites W2023198553 @default.
- W2017733095 cites W2025498861 @default.
- W2017733095 cites W2031423487 @default.
- W2017733095 cites W2052666471 @default.
- W2017733095 cites W2090231975 @default.
- W2017733095 cites W2116346771 @default.
- W2017733095 cites W2147392418 @default.
- W2017733095 cites W2150064963 @default.
- W2017733095 cites W2205439823 @default.
- W2017733095 doi "https://doi.org/10.1002/bdd.2510160707" @default.
- W2017733095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8785382" @default.
- W2017733095 hasPublicationYear "1995" @default.
- W2017733095 type Work @default.
- W2017733095 sameAs 2017733095 @default.
- W2017733095 citedByCount "10" @default.
- W2017733095 countsByYear W20177330952015 @default.
- W2017733095 countsByYear W20177330952016 @default.
- W2017733095 countsByYear W20177330952017 @default.
- W2017733095 crossrefType "journal-article" @default.
- W2017733095 hasAuthorship W2017733095A5031938815 @default.
- W2017733095 hasAuthorship W2017733095A5041858502 @default.
- W2017733095 hasAuthorship W2017733095A5052862047 @default.
- W2017733095 hasAuthorship W2017733095A5068527814 @default.
- W2017733095 hasAuthorship W2017733095A5077475492 @default.
- W2017733095 hasAuthorship W2017733095A5086059561 @default.
- W2017733095 hasAuthorship W2017733095A5087497175 @default.
- W2017733095 hasAuthorship W2017733095A5091761204 @default.
- W2017733095 hasConcept C112705442 @default.
- W2017733095 hasConcept C126322002 @default.
- W2017733095 hasConcept C134018914 @default.
- W2017733095 hasConcept C181199279 @default.
- W2017733095 hasConcept C185592680 @default.
- W2017733095 hasConcept C2777056448 @default.
- W2017733095 hasConcept C2778033501 @default.
- W2017733095 hasConcept C2780091579 @default.
- W2017733095 hasConcept C2909935303 @default.
- W2017733095 hasConcept C2911091166 @default.
- W2017733095 hasConcept C43617362 @default.
- W2017733095 hasConcept C55493867 @default.
- W2017733095 hasConcept C71924100 @default.
- W2017733095 hasConcept C98274493 @default.
- W2017733095 hasConceptScore W2017733095C112705442 @default.
- W2017733095 hasConceptScore W2017733095C126322002 @default.
- W2017733095 hasConceptScore W2017733095C134018914 @default.
- W2017733095 hasConceptScore W2017733095C181199279 @default.
- W2017733095 hasConceptScore W2017733095C185592680 @default.
- W2017733095 hasConceptScore W2017733095C2777056448 @default.
- W2017733095 hasConceptScore W2017733095C2778033501 @default.
- W2017733095 hasConceptScore W2017733095C2780091579 @default.
- W2017733095 hasConceptScore W2017733095C2909935303 @default.
- W2017733095 hasConceptScore W2017733095C2911091166 @default.
- W2017733095 hasConceptScore W2017733095C43617362 @default.
- W2017733095 hasConceptScore W2017733095C55493867 @default.
- W2017733095 hasConceptScore W2017733095C71924100 @default.
- W2017733095 hasConceptScore W2017733095C98274493 @default.
- W2017733095 hasIssue "7" @default.
- W2017733095 hasLocation W20177330951 @default.
- W2017733095 hasLocation W20177330952 @default.
- W2017733095 hasOpenAccess W2017733095 @default.
- W2017733095 hasPrimaryLocation W20177330951 @default.
- W2017733095 hasRelatedWork W1974696155 @default.
- W2017733095 hasRelatedWork W1986646557 @default.
- W2017733095 hasRelatedWork W2016273346 @default.
- W2017733095 hasRelatedWork W2092357333 @default.
- W2017733095 hasRelatedWork W2104585255 @default.
- W2017733095 hasRelatedWork W2114247609 @default.
- W2017733095 hasRelatedWork W2333467312 @default.
- W2017733095 hasRelatedWork W2406547677 @default.
- W2017733095 hasRelatedWork W2413823926 @default.
- W2017733095 hasRelatedWork W2416371676 @default.
- W2017733095 hasVolume "16" @default.
- W2017733095 isParatext "false" @default.
- W2017733095 isRetracted "false" @default.
- W2017733095 magId "2017733095" @default.
- W2017733095 workType "article" @default.