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- W2017743111 abstract "A case of primary leptomeningeal melanoma is presented in which the diagnosis was made by ultrastructural demonstration of melanoma cells from the cerebrospinal fluid (CSF) at a time when cranial computed tomography (CT) still gave negative results. Later CT examinations documented the emergence of a tumor mass of the left temporoparietal lobe. This case clearly illustrates the complementary role of these investigational procedures for the diagnosis of cerebrospinal melanoma: leptomeningeal involvement, characterized by two-dimensional diffuse spread of melanoma tissue (leptomeningeal melanomatosis), is invisible with CT, but easily recognisable by CSF cytology; in contrast, nodular parenchymal tumor deposits can be readily detected by CT. Identification of pigmented cells recovered from the CSF requires ultrastructural confirmation." @default.
- W2017743111 created "2016-06-24" @default.
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- W2017743111 date "1982-11-01" @default.
- W2017743111 modified "2023-09-23" @default.
- W2017743111 title "Primary leptomeningeal melanoma. Diagnosis by ultrastructural cytology of cerebrospinal fluid and cranial computed tomography" @default.
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- W2017743111 doi "https://doi.org/10.1002/1097-0142(19821101)50:9<1751::aid-cncr2820500918>3.0.co;2-q" @default.
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