FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017748321> ?p ?o ?g. }

• W2017748321 endingPage "e100579" @default.
• W2017748321 startingPage "e100579" @default.
• W2017748321 abstract "High-fat diet with obesity-associated co-morbidities triggers cardiac remodeling and renders the heart more vulnerable to ischemia/reperfusion injury. However, the effect of high-fat diet without obesity and associated co-morbidities is presently unknown.To characterize a non-obese mouse model of high-fat diet, assess the vulnerability of hearts to reperfusion injury and to investigate cardiac cellular remodeling in relation to the mechanism(s) underlying reperfusion injury.Feeding C57BL/6J male mice high-fat diet for 20 weeks did not induce obesity, diabetes, cardiac hypertrophy, cardiac dysfunction, atherosclerosis or cardiac apoptosis. However, isolated perfused hearts from mice fed high-fat diet were more vulnerable to reperfusion injury than those from mice fed normal diet. In isolated cardiomyocytes, high-fat diet was associated with higher diastolic intracellular Ca2+ concentration and greater damage to isolated cardiomyocytes following simulated ischemia/reperfusion. High-fat diet was also associated with changes in mitochondrial morphology and expression of some related proteins but not mitochondrial respiration or reactive oxygen species turnover rates. Proteomics, western blot and high-performance liquid chromatography techniques revealed that high-fat diet led to less cardiac oxidative stress, higher catalase expression and significant changes in expression of putative components of the mitochondrial permeability transition pore (mPTP). Inhibition of the mPTP conferred relatively more cardio-protection in the high-fat fed mice compared to normal diet.This study shows for the first time that high-fat diet, independent of obesity-induced co-morbidities, triggers changes in cardiac oxidative state, calcium handling and mitochondria which are likely to be responsible for increased vulnerability to cardiac insults." @default.
• W2017748321 created "2016-06-24" @default.
• W2017748321 creator A5015900831 @default.
• W2017748321 creator A5019200149 @default.
• W2017748321 creator A5020881219 @default.
• W2017748321 creator A5045975776 @default.
• W2017748321 creator A5054764500 @default.
• W2017748321 creator A5061020486 @default.
• W2017748321 creator A5062819756 @default.
• W2017748321 creator A5076265294 @default.
• W2017748321 creator A5091872419 @default.
• W2017748321 date "2014-06-20" @default.
• W2017748321 modified "2023-09-30" @default.
• W2017748321 title "Hearts from Mice Fed a Non-Obesogenic High-Fat Diet Exhibit Changes in Their Oxidative State, Calcium and Mitochondria in Parallel with Increased Susceptibility to Reperfusion Injury" @default.
• W2017748321 cites W145720774 @default.
• W2017748321 cites W1513077899 @default.
• W2017748321 cites W1529482896 @default.
• W2017748321 cites W1813230101 @default.
• W2017748321 cites W1826492881 @default.
• W2017748321 cites W1909302202 @default.
• W2017748321 cites W1964434851 @default.
• W2017748321 cites W1971604090 @default.
• W2017748321 cites W1973145108 @default.
• W2017748321 cites W1973281235 @default.
• W2017748321 cites W1979714251 @default.
• W2017748321 cites W1982723196 @default.
• W2017748321 cites W1991439925 @default.
• W2017748321 cites W1991863384 @default.
• W2017748321 cites W1996166472 @default.
• W2017748321 cites W1996738096 @default.
• W2017748321 cites W1999835438 @default.
• W2017748321 cites W2017604990 @default.
• W2017748321 cites W2018031473 @default.
• W2017748321 cites W2019446944 @default.
• W2017748321 cites W2025555937 @default.
• W2017748321 cites W2035050651 @default.
• W2017748321 cites W2035695619 @default.
• W2017748321 cites W2037572308 @default.
• W2017748321 cites W2037740326 @default.
• W2017748321 cites W2046741327 @default.
• W2017748321 cites W2047254934 @default.
• W2017748321 cites W2048243122 @default.
• W2017748321 cites W2048607634 @default.
• W2017748321 cites W2053073250 @default.
• W2017748321 cites W2055324514 @default.
• W2017748321 cites W2056245899 @default.
• W2017748321 cites W2059477502 @default.
• W2017748321 cites W2060671236 @default.
• W2017748321 cites W2060896332 @default.
• W2017748321 cites W2063284227 @default.
• W2017748321 cites W2064263174 @default.
• W2017748321 cites W2065623326 @default.
• W2017748321 cites W2069872642 @default.
• W2017748321 cites W2070944220 @default.
• W2017748321 cites W2076687053 @default.
• W2017748321 cites W2085367705 @default.
• W2017748321 cites W2090709421 @default.
• W2017748321 cites W2091683736 @default.
• W2017748321 cites W2092685208 @default.
• W2017748321 cites W2097049860 @default.
• W2017748321 cites W2098612318 @default.
• W2017748321 cites W2102382961 @default.
• W2017748321 cites W2102526205 @default.
• W2017748321 cites W2104096838 @default.
• W2017748321 cites W2105265053 @default.
• W2017748321 cites W2106204941 @default.
• W2017748321 cites W2107030671 @default.
• W2017748321 cites W2113976720 @default.
• W2017748321 cites W2115101707 @default.
• W2017748321 cites W2116900516 @default.
• W2017748321 cites W2120379299 @default.
• W2017748321 cites W2121330845 @default.
• W2017748321 cites W2122954934 @default.
• W2017748321 cites W2128606426 @default.
• W2017748321 cites W2130906765 @default.
• W2017748321 cites W2131666074 @default.
• W2017748321 cites W2133992379 @default.
• W2017748321 cites W2137438717 @default.
• W2017748321 cites W2138201763 @default.
• W2017748321 cites W2140580197 @default.
• W2017748321 cites W2145490597 @default.
• W2017748321 cites W2148401509 @default.
• W2017748321 cites W2152865324 @default.
• W2017748321 cites W2155622682 @default.
• W2017748321 cites W2162422162 @default.
• W2017748321 cites W2164023695 @default.
• W2017748321 cites W2164671913 @default.
• W2017748321 cites W2164721799 @default.
• W2017748321 cites W2166432730 @default.
• W2017748321 cites W2166788192 @default.
• W2017748321 cites W2168958159 @default.
• W2017748321 doi "https://doi.org/10.1371/journal.pone.0100579" @default.
• W2017748321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4065057" @default.
• W2017748321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24950187" @default.
• W2017748321 hasPublicationYear "2014" @default.
• W2017748321 type Work @default.
• W2017748321 sameAs 2017748321 @default.
• W2017748321 citedByCount "50" @default.

• next