FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017751019> ?p ?o ?g. }

• W2017751019 endingPage "371" @default.
• W2017751019 startingPage "365" @default.
• W2017751019 abstract "The 2′-deoxy-2′-methylene derivatives of adenosine (MdAdo), guanosine (MdGuo), tubercidin (MdTu), cytidine (MdCyd) and undine (MdUrd) were synthesized as mechanism-based inhibitors directed at ribonucleotide reductase. It was shown that MdCyd 5′-diphosphate irreversibly inactivated ribonucleotide reductase from Escherichia coli (Baker et al., J Med Chem34: 1879–1884, 1991). In studies reported here, MdAdo/EHNA, MdGuo and MdCyd inhibited L1210 cell growth with IC50 values of 3.4,10.6 and 1.4 μM, respectively. Since MdAdo is a substrate for adenosine deaminase, the presence of EHNA was required to give maximal growth inhibition. 8-Aminoguanosine was not required to maximize the cytotoxic effects of MdGuo. The 2′-deoxy-2′-methylene derivatives of tubercidin and uridine did not inhibit L1210 cell growth at concentrations as high as 50 μM (MdTu) or 100 μM (MdUrd). L1210 cell lines resistant to hydroxyurea (directed at the non-heme iron subunit of ribonucleotide reductase) or deoxyadenosine (directed at the effector binding subunit of ribonucleotide reductase) were not resistant to MdCyd. An L1210 cell line that. was highly resistant to dGuo due to the loss of a relatively specific deoxyribonucleoside kinase (Cory et al., J Biol Chem268: 405–409, 1993) had a 6.6 fold increase in the IC50 value toward MdCyd, but showed only a 2-fold increase in resistance to MdGuo. Another L1210 cell line that was markedly deficient in adenosine kinase activity was highly resistant to MdAdo. Analysis by now cytometry showed that MdCyd slowed the transit of the cells through the G2/M phase of the cell cycle resulting in the buildup of the G2/M population. MdAdo, MdGuo and MdCyd inhibited the incorporation of [14C]cytidine into DNA without an effect on RNA synthesis or total cellular uptake of [14C]cytidine. The conversion of [14C]cytidine to deoxycytidine nucleotides was partially inhibited by MdGuo, but not by MdAdo or MdCyd. These data show that the 2′-deoxy-2′-methylene derivatives of adenosine, guanosine and cytidine are activated via specific nucleoside kinases and that the modes of action of these compounds are not identical." @default.
• W2017751019 created "2016-06-24" @default.
• W2017751019 creator A5003486674 @default.
• W2017751019 creator A5030439450 @default.
• W2017751019 creator A5053874300 @default.
• W2017751019 creator A5082444475 @default.
• W2017751019 date "1994-01-01" @default.
• W2017751019 modified "2023-10-17" @default.
• W2017751019 title "2′-deoxy-2′-methylene derivatives of adenosine, guanosine, tubercidin, cytidine and uridine as inhibitors of L1210 cell growth in culture" @default.
• W2017751019 cites W1563948625 @default.
• W2017751019 cites W1575296448 @default.
• W2017751019 cites W1602075271 @default.
• W2017751019 cites W1775749144 @default.
• W2017751019 cites W1896066594 @default.
• W2017751019 cites W1966801404 @default.
• W2017751019 cites W1970401552 @default.
• W2017751019 cites W1975075504 @default.
• W2017751019 cites W1977777045 @default.
• W2017751019 cites W1993491727 @default.
• W2017751019 cites W2015372158 @default.
• W2017751019 cites W2016553269 @default.
• W2017751019 cites W2042662803 @default.
• W2017751019 cites W2046143580 @default.
• W2017751019 cites W2054137828 @default.
• W2017751019 cites W2068973845 @default.
• W2017751019 cites W2076316345 @default.
• W2017751019 cites W2125375985 @default.
• W2017751019 cites W2169790726 @default.
• W2017751019 cites W2274550965 @default.
• W2017751019 cites W2464426841 @default.
• W2017751019 cites W2952479816 @default.
• W2017751019 doi "https://doi.org/10.1016/0006-2952(94)90028-0" @default.
• W2017751019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8304981" @default.
• W2017751019 hasPublicationYear "1994" @default.
• W2017751019 type Work @default.
• W2017751019 sameAs 2017751019 @default.
• W2017751019 citedByCount "18" @default.
• W2017751019 countsByYear W20177510192017 @default.
• W2017751019 countsByYear W20177510192018 @default.
• W2017751019 crossrefType "journal-article" @default.
• W2017751019 hasAuthorship W2017751019A5003486674 @default.
• W2017751019 hasAuthorship W2017751019A5030439450 @default.
• W2017751019 hasAuthorship W2017751019A5053874300 @default.
• W2017751019 hasAuthorship W2017751019A5082444475 @default.
• W2017751019 hasConcept C104292427 @default.
• W2017751019 hasConcept C104317684 @default.
• W2017751019 hasConcept C109316439 @default.
• W2017751019 hasConcept C153911025 @default.
• W2017751019 hasConcept C181199279 @default.
• W2017751019 hasConcept C185592680 @default.
• W2017751019 hasConcept C202751555 @default.
• W2017751019 hasConcept C2776543447 @default.
• W2017751019 hasConcept C2776770532 @default.
• W2017751019 hasConcept C2776991684 @default.
• W2017751019 hasConcept C2777995097 @default.
• W2017751019 hasConcept C2780017796 @default.
• W2017751019 hasConcept C2780636463 @default.
• W2017751019 hasConcept C2781184954 @default.
• W2017751019 hasConcept C2781259782 @default.
• W2017751019 hasConcept C2909627636 @default.
• W2017751019 hasConcept C34628245 @default.
• W2017751019 hasConcept C4710235 @default.
• W2017751019 hasConcept C512185932 @default.
• W2017751019 hasConcept C55493867 @default.
• W2017751019 hasConcept C67705224 @default.
• W2017751019 hasConcept C86803240 @default.
• W2017751019 hasConcept C98892162 @default.
• W2017751019 hasConceptScore W2017751019C104292427 @default.
• W2017751019 hasConceptScore W2017751019C104317684 @default.
• W2017751019 hasConceptScore W2017751019C109316439 @default.
• W2017751019 hasConceptScore W2017751019C153911025 @default.
• W2017751019 hasConceptScore W2017751019C181199279 @default.
• W2017751019 hasConceptScore W2017751019C185592680 @default.
• W2017751019 hasConceptScore W2017751019C202751555 @default.
• W2017751019 hasConceptScore W2017751019C2776543447 @default.
• W2017751019 hasConceptScore W2017751019C2776770532 @default.
• W2017751019 hasConceptScore W2017751019C2776991684 @default.
• W2017751019 hasConceptScore W2017751019C2777995097 @default.
• W2017751019 hasConceptScore W2017751019C2780017796 @default.
• W2017751019 hasConceptScore W2017751019C2780636463 @default.
• W2017751019 hasConceptScore W2017751019C2781184954 @default.
• W2017751019 hasConceptScore W2017751019C2781259782 @default.
• W2017751019 hasConceptScore W2017751019C2909627636 @default.
• W2017751019 hasConceptScore W2017751019C34628245 @default.
• W2017751019 hasConceptScore W2017751019C4710235 @default.
• W2017751019 hasConceptScore W2017751019C512185932 @default.
• W2017751019 hasConceptScore W2017751019C55493867 @default.
• W2017751019 hasConceptScore W2017751019C67705224 @default.
• W2017751019 hasConceptScore W2017751019C86803240 @default.
• W2017751019 hasConceptScore W2017751019C98892162 @default.
• W2017751019 hasIssue "2" @default.
• W2017751019 hasLocation W20177510191 @default.
• W2017751019 hasLocation W20177510192 @default.
• W2017751019 hasOpenAccess W2017751019 @default.
• W2017751019 hasPrimaryLocation W20177510191 @default.
• W2017751019 hasRelatedWork W2027278083 @default.
• W2017751019 hasRelatedWork W2079752228 @default.
• W2017751019 hasRelatedWork W2093323025 @default.

• next