FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017752671> ?p ?o ?g. }

• W2017752671 endingPage "162" @default.
• W2017752671 startingPage "157" @default.
• W2017752671 abstract "The calciotropic hormone 1α,25-dihydroxy-vitamin D3 (1,25(OH)2D3) has been shown to stimulate both rat and chick myoblast 45Ca2+ uptake via modulation of dihydropyridine-sensitive L-type calcium channels through phosphorylation by the cAMP/protein kinase A pathway. We further investigated the involvement of protein kinases in 1,25(OH)2D3-signal transduction on cultured myoblasts. The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) was found to rapidly stimulate myoblast 45Ca2+ uptake, mimicking 1,25(OH)2D3. The effects of PMA were time- (1–5 min) and dose (50–100 nM)-dependent, were mimicked by 1,2-dioctanoylglycerol (DOG) and were specific, since the inactive analogue 4α-phorbol was without effect. Analogously to the hormone, PMA-enhanced 45Ca2+ uptake was suppressed by the Ca2+-channel blocker nifedipine (5 μM). 1-(5-isoquinolynsulfonyl)-2-methyl-piperazine (H-7), a PKC inhibitor, and down-regulation of PKC by prolonged exposure to PMA (1 μM, 24 h), abolished both PMA and hormone effects on rat and chick cells. As in chick myoblasts, 1,25(OH)22D3 activated PKC in rat myoblasts, with translocation of activity from the cytosol to the cell membrane. Treatment of myoblasts with PMA (100 nM) plus 1,25(OH)2D3 (1 nM) greatly potentiated 45Ca2+ uptake than either agent alone. PMA also increased myoblast cAMP content. These results suggest the involvement of PKC in the mechanism by which 1,255(OH)2D3 rapidly stimulates calcium uptake in both mammalian and avian myoblasts." @default.
• W2017752671 created "2016-06-24" @default.
• W2017752671 creator A5059268113 @default.
• W2017752671 creator A5086726315 @default.
• W2017752671 date "1996-01-01" @default.
• W2017752671 modified "2023-10-17" @default.
• W2017752671 title "Involvement of protein kinase C in the modulation of 1α,25-dihydroxy-vitamin D3-induced 45Ca2+ uptake in rat and chick cultured myoblasts" @default.
• W2017752671 cites W1045314443 @default.
• W2017752671 cites W1521493025 @default.
• W2017752671 cites W1530270875 @default.
• W2017752671 cites W1775749144 @default.
• W2017752671 cites W1854781184 @default.
• W2017752671 cites W1899877571 @default.
• W2017752671 cites W194629505 @default.
• W2017752671 cites W1964839077 @default.
• W2017752671 cites W1965154398 @default.
• W2017752671 cites W1973454785 @default.
• W2017752671 cites W1976386179 @default.
• W2017752671 cites W1978619006 @default.
• W2017752671 cites W1979893127 @default.
• W2017752671 cites W1985726590 @default.
• W2017752671 cites W1996626314 @default.
• W2017752671 cites W1997442781 @default.
• W2017752671 cites W2001692359 @default.
• W2017752671 cites W2003436933 @default.
• W2017752671 cites W2006192148 @default.
• W2017752671 cites W2012533092 @default.
• W2017752671 cites W2027047679 @default.
• W2017752671 cites W2045064061 @default.
• W2017752671 cites W2050943200 @default.
• W2017752671 cites W2054362917 @default.
• W2017752671 cites W2067864810 @default.
• W2017752671 cites W2091177356 @default.
• W2017752671 cites W2108175078 @default.
• W2017752671 cites W2121294572 @default.
• W2017752671 cites W2140314600 @default.
• W2017752671 cites W2149637850 @default.
• W2017752671 cites W2291664211 @default.
• W2017752671 doi "https://doi.org/10.1016/0167-4889(95)00158-1" @default.
• W2017752671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9244190" @default.
• W2017752671 hasPublicationYear "1996" @default.
• W2017752671 type Work @default.
• W2017752671 sameAs 2017752671 @default.
• W2017752671 citedByCount "46" @default.
• W2017752671 countsByYear W20177526712012 @default.
• W2017752671 countsByYear W20177526712018 @default.
• W2017752671 countsByYear W20177526712019 @default.
• W2017752671 countsByYear W20177526712020 @default.
• W2017752671 countsByYear W20177526712023 @default.
• W2017752671 crossrefType "journal-article" @default.
• W2017752671 hasAuthorship W2017752671A5059268113 @default.
• W2017752671 hasAuthorship W2017752671A5086726315 @default.
• W2017752671 hasConcept C126322002 @default.
• W2017752671 hasConcept C134018914 @default.
• W2017752671 hasConcept C170493617 @default.
• W2017752671 hasConcept C181199279 @default.
• W2017752671 hasConcept C184235292 @default.
• W2017752671 hasConcept C185592680 @default.
• W2017752671 hasConcept C195794163 @default.
• W2017752671 hasConcept C207200792 @default.
• W2017752671 hasConcept C2780043322 @default.
• W2017752671 hasConcept C2781212610 @default.
• W2017752671 hasConcept C519063684 @default.
• W2017752671 hasConcept C55493867 @default.
• W2017752671 hasConcept C71924100 @default.
• W2017752671 hasConcept C86803240 @default.
• W2017752671 hasConcept C88045685 @default.
• W2017752671 hasConcept C97029542 @default.
• W2017752671 hasConcept C98539663 @default.
• W2017752671 hasConceptScore W2017752671C126322002 @default.
• W2017752671 hasConceptScore W2017752671C134018914 @default.
• W2017752671 hasConceptScore W2017752671C170493617 @default.
• W2017752671 hasConceptScore W2017752671C181199279 @default.
• W2017752671 hasConceptScore W2017752671C184235292 @default.
• W2017752671 hasConceptScore W2017752671C185592680 @default.
• W2017752671 hasConceptScore W2017752671C195794163 @default.
• W2017752671 hasConceptScore W2017752671C207200792 @default.
• W2017752671 hasConceptScore W2017752671C2780043322 @default.
• W2017752671 hasConceptScore W2017752671C2781212610 @default.
• W2017752671 hasConceptScore W2017752671C519063684 @default.
• W2017752671 hasConceptScore W2017752671C55493867 @default.
• W2017752671 hasConceptScore W2017752671C71924100 @default.
• W2017752671 hasConceptScore W2017752671C86803240 @default.
• W2017752671 hasConceptScore W2017752671C88045685 @default.
• W2017752671 hasConceptScore W2017752671C97029542 @default.
• W2017752671 hasConceptScore W2017752671C98539663 @default.
• W2017752671 hasIssue "1" @default.
• W2017752671 hasLocation W20177526711 @default.
• W2017752671 hasLocation W20177526712 @default.
• W2017752671 hasOpenAccess W2017752671 @default.
• W2017752671 hasPrimaryLocation W20177526711 @default.
• W2017752671 hasRelatedWork W1968234224 @default.
• W2017752671 hasRelatedWork W1975286344 @default.
• W2017752671 hasRelatedWork W1993329902 @default.
• W2017752671 hasRelatedWork W2022445643 @default.
• W2017752671 hasRelatedWork W2026913891 @default.
• W2017752671 hasRelatedWork W2029870587 @default.
• W2017752671 hasRelatedWork W2084059091 @default.

• next