FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017755619> ?p ?o ?g. }

• W2017755619 endingPage "293" @default.
• W2017755619 startingPage "286" @default.
• W2017755619 abstract "Apoptosis is an active form of cell death which plays an important role in different biological processes. The induction of apoptosis usually requires de novo gene expression but has also been observed in certain types of cells in absence of gene expression or following a block of gene expression. We show here that inhibition of macromolecular synthesis induced the rapid apoptotic death of most antibody-secreting B-cell hybridomas. The effect was observed in presence of both protein synthesis (cycloheximide [CHX]) and transcription (actinomycin D [Act D]) inhibitors and was characterized by extensive degradation of nucleic acids (DNA and RNA) within 2-3 h of treatment. The CHX treatment not only severely impaired the proliferation of the cells but also resulted in the loss of cell viability (MTT assay) without the need of de novo gene expression. The susceptibility to apoptosis varied among different B-cell hybridomas and was inherited from the SP2/0 myeloma cell fusion partner. These results indicate the constitutive activation of a death program in B-cell hybridomas and its inhibition at a late stage by the continuous expression of gene(s) coding for short-lived protein(s). The occurrence of this phenomenon may well be related to the abundant and deregulated (translocation) expression, in this type of cells, of the c-myc gene which has recently been shown to be a potent inducer of apoptosis in growth-arrested fibroblasts." @default.
• W2017755619 created "2016-06-24" @default.
• W2017755619 creator A5001493416 @default.
• W2017755619 creator A5059209306 @default.
• W2017755619 date "1993-08-01" @default.
• W2017755619 modified "2023-10-01" @default.
• W2017755619 title "Rapid apoptotic cell death of B-cell hybridomas in absence of gene expression" @default.
• W2017755619 cites W1485476587 @default.
• W2017755619 cites W1547820142 @default.
• W2017755619 cites W1565761678 @default.
• W2017755619 cites W1589415602 @default.
• W2017755619 cites W1605973129 @default.
• W2017755619 cites W1665581185 @default.
• W2017755619 cites W1832527043 @default.
• W2017755619 cites W1862346079 @default.
• W2017755619 cites W1873458020 @default.
• W2017755619 cites W1963939397 @default.
• W2017755619 cites W1965854549 @default.
• W2017755619 cites W1967787805 @default.
• W2017755619 cites W1974869964 @default.
• W2017755619 cites W1980224338 @default.
• W2017755619 cites W1984332162 @default.
• W2017755619 cites W1990615139 @default.
• W2017755619 cites W1991605327 @default.
• W2017755619 cites W2003501749 @default.
• W2017755619 cites W2011710311 @default.
• W2017755619 cites W2019400899 @default.
• W2017755619 cites W2019410656 @default.
• W2017755619 cites W2021048148 @default.
• W2017755619 cites W2026452824 @default.
• W2017755619 cites W2030522563 @default.
• W2017755619 cites W2049926072 @default.
• W2017755619 cites W2054526986 @default.
• W2017755619 cites W2057257609 @default.
• W2017755619 cites W2064735501 @default.
• W2017755619 cites W2076244999 @default.
• W2017755619 cites W2081948388 @default.
• W2017755619 cites W2084609653 @default.
• W2017755619 cites W2085214231 @default.
• W2017755619 cites W2091673136 @default.
• W2017755619 cites W2101462909 @default.
• W2017755619 cites W2114882367 @default.
• W2017755619 cites W2157786523 @default.
• W2017755619 cites W2164515753 @default.
• W2017755619 cites W2178615409 @default.
• W2017755619 cites W4233484287 @default.
• W2017755619 doi "https://doi.org/10.1002/jcp.1041560210" @default.
• W2017755619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7688371" @default.
• W2017755619 hasPublicationYear "1993" @default.
• W2017755619 type Work @default.
• W2017755619 sameAs 2017755619 @default.
• W2017755619 citedByCount "30" @default.
• W2017755619 countsByYear W20177556192015 @default.
• W2017755619 countsByYear W20177556192017 @default.
• W2017755619 crossrefType "journal-article" @default.
• W2017755619 hasAuthorship W2017755619A5001493416 @default.
• W2017755619 hasAuthorship W2017755619A5059209306 @default.
• W2017755619 hasConcept C104317684 @default.
• W2017755619 hasConcept C111829193 @default.
• W2017755619 hasConcept C150194340 @default.
• W2017755619 hasConcept C153911025 @default.
• W2017755619 hasConcept C190283241 @default.
• W2017755619 hasConcept C2225953 @default.
• W2017755619 hasConcept C2778128677 @default.
• W2017755619 hasConcept C31573885 @default.
• W2017755619 hasConcept C3675279 @default.
• W2017755619 hasConcept C55493867 @default.
• W2017755619 hasConcept C62112901 @default.
• W2017755619 hasConcept C86803240 @default.
• W2017755619 hasConcept C95444343 @default.
• W2017755619 hasConceptScore W2017755619C104317684 @default.
• W2017755619 hasConceptScore W2017755619C111829193 @default.
• W2017755619 hasConceptScore W2017755619C150194340 @default.
• W2017755619 hasConceptScore W2017755619C153911025 @default.
• W2017755619 hasConceptScore W2017755619C190283241 @default.
• W2017755619 hasConceptScore W2017755619C2225953 @default.
• W2017755619 hasConceptScore W2017755619C2778128677 @default.
• W2017755619 hasConceptScore W2017755619C31573885 @default.
• W2017755619 hasConceptScore W2017755619C3675279 @default.
• W2017755619 hasConceptScore W2017755619C55493867 @default.
• W2017755619 hasConceptScore W2017755619C62112901 @default.
• W2017755619 hasConceptScore W2017755619C86803240 @default.
• W2017755619 hasConceptScore W2017755619C95444343 @default.
• W2017755619 hasIssue "2" @default.
• W2017755619 hasLocation W20177556191 @default.
• W2017755619 hasLocation W20177556192 @default.
• W2017755619 hasOpenAccess W2017755619 @default.
• W2017755619 hasPrimaryLocation W20177556191 @default.
• W2017755619 hasRelatedWork W1893780161 @default.
• W2017755619 hasRelatedWork W1987695408 @default.
• W2017755619 hasRelatedWork W2005722654 @default.
• W2017755619 hasRelatedWork W2008949082 @default.
• W2017755619 hasRelatedWork W2009966535 @default.
• W2017755619 hasRelatedWork W2017755619 @default.
• W2017755619 hasRelatedWork W2055361194 @default.
• W2017755619 hasRelatedWork W2064973017 @default.
• W2017755619 hasRelatedWork W2108237850 @default.
• W2017755619 hasRelatedWork W2121095034 @default.

• next