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- W2017756102 abstract "One characteristic of plasticity after peripheral tissue or nerve damage is receptive field reorganization, and enlargement of receptive field size has been suggested to occur in certain models of neuropathic pain. The aim of the present study was to explore whether enlargement of neuronal receptive fields could contribute to the mechanical allodynia found on the ipsilateral paw in the spinal nerve ligation model of neuropathy. After ligation of L5–L6 spinal nerves, all rats developed behavioral signs of mechanical allodynia, while the sham-operated control group displayed no such changes. The characteristics of the evoked responses of the neurones recorded in the dorsal horn of the rats were similar between the spinal nerve ligation, the sham operated control group, and the nonoperated control group, except for spontaneous activity, which was significantly increased in the spinal nerve ligation group. The mean size of the receptive field on the ipsilateral hindpaw, mapped using low-intensity stimulation with 9-g von Frey hair, was significantly increased in the spinal nerve ligation group, as compared to the sham-operated group. No significant difference was seen with 15- or 75-g von Frey hairs. The distribution of the receptive fields over the plantar surface of the paw was similar between the study groups. The enlargement of receptive field for nonnoxious touch could be an indication of central sensitization in this model." @default.
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- W2017756102 date "2000-06-01" @default.
- W2017756102 modified "2023-09-27" @default.
- W2017756102 title "Enlargement of the Receptive Field Size to Low Intensity Mechanical Stimulation in the Rat Spinal Nerve Ligation Model of Neuropathy" @default.
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- W2017756102 doi "https://doi.org/10.1006/exnr.2000.7371" @default.
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