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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017757465> ?p ?o ?g. }

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• W2017757465 abstract "A series of azolylmethyloxolane derivatives with modified sterol side-chain structures, designed as potential dual functional inhibitors of cytochrome P450 14α-demethylase (14DM) and Δ24-sterol methyltransferase (24-SMT) based on the common characteristic features of 24-aminosterols and azole antifungal agents, were synthesized and evaluated for their antifungal activities and inhibitory activities of 14DM and 24-SMT. Among these compounds, imidazolylmethyloxolane derivatives 28a and 28b showed potent in vitro antifungal activities comparable to those of itraconazole. However, the in vitro bioactivities have not been linearly translated into in vivo protection data for some unknown reasons." @default.
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• W2017757465 date "2000-10-01" @default.
• W2017757465 modified "2023-10-17" @default.
• W2017757465 title "Design and synthesis of potential inhibitors of the ergosterol biosynthesis as antifungal agents" @default.
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• W2017757465 doi "https://doi.org/10.1016/s0968-0896(00)00177-2" @default.
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