Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017759462> ?p ?o ?g. }
- W2017759462 endingPage "51" @default.
- W2017759462 startingPage "42" @default.
- W2017759462 abstract "In earlier studies, the volatile anesthetics and the endogenous cannabinoid anandamide have been shown to inhibit the function of α7-nicotinic acetylcholine receptors. In the present study, interactions between the effects of volatile anesthetics and anandamide on the function of α7-nicotinic acetylcholine receptors expressed in Xenopus oocytes were investigated using the two-electrode voltage-clamp technique. Anandamide and volatile anesthetics isoflurane and halothane inhibited currents evoked with acetylcholine (100 μM) in a reversible and concentration-dependent manner. Coapplication of anandamide and volatile anesthetics caused a significantly greater inhibition of α7-nicotinic acetylcholine receptor function than anandamide or volatile anesthetics alone. Analyses of oocytes by matrix-assisted laser desorption/ionization mass spectroscopy indicated that volatile anesthetics did not alter the lipid profile of oocytes. Results of studies with chimeric α7-nicotinic acetylcholine-5-HT3 receptors comprised of the N-terminal domain of the α7-nicotinic acetylcholine receptor and the transmembrane and carboxyl-terminal domains of 5-HT3 receptors suggest that while isoflurane inhibition of the α7-nicotinic acetylcholine receptor is likely to involve the N-terminal region of the receptor, the site of action for anandamide involves transmembrane and carboxyl-terminal domains of the receptors. These data indicate that endocannabinoids and isoflurane have additive inhibitory effects on α7-nicotinic acetylcholine receptor function through allosteric binding sites located on the distinct regions of the receptor." @default.
- W2017759462 created "2016-06-24" @default.
- W2017759462 creator A5005147999 @default.
- W2017759462 creator A5016267513 @default.
- W2017759462 creator A5045595920 @default.
- W2017759462 creator A5052895314 @default.
- W2017759462 creator A5052939200 @default.
- W2017759462 creator A5066716873 @default.
- W2017759462 creator A5069741153 @default.
- W2017759462 date "2008-03-01" @default.
- W2017759462 modified "2023-09-24" @default.
- W2017759462 title "Volatile anesthetics and endogenous cannabinoid anandamide have additive and independent inhibitory effects on α7-nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes" @default.
- W2017759462 cites W1430574716 @default.
- W2017759462 cites W1511180457 @default.
- W2017759462 cites W1541419413 @default.
- W2017759462 cites W1545439706 @default.
- W2017759462 cites W1592840721 @default.
- W2017759462 cites W1668093331 @default.
- W2017759462 cites W1755477571 @default.
- W2017759462 cites W1965454986 @default.
- W2017759462 cites W1976057608 @default.
- W2017759462 cites W1978982490 @default.
- W2017759462 cites W1983565109 @default.
- W2017759462 cites W1984051697 @default.
- W2017759462 cites W1987915424 @default.
- W2017759462 cites W2001893528 @default.
- W2017759462 cites W2007265649 @default.
- W2017759462 cites W2007578821 @default.
- W2017759462 cites W2013950084 @default.
- W2017759462 cites W2015066232 @default.
- W2017759462 cites W2015109725 @default.
- W2017759462 cites W2016352832 @default.
- W2017759462 cites W2018115671 @default.
- W2017759462 cites W2022819833 @default.
- W2017759462 cites W2027885602 @default.
- W2017759462 cites W2030451380 @default.
- W2017759462 cites W2032150201 @default.
- W2017759462 cites W2036790219 @default.
- W2017759462 cites W2053243627 @default.
- W2017759462 cites W2054250221 @default.
- W2017759462 cites W2055025526 @default.
- W2017759462 cites W2056292058 @default.
- W2017759462 cites W2058619238 @default.
- W2017759462 cites W2060150631 @default.
- W2017759462 cites W2062614777 @default.
- W2017759462 cites W2063781776 @default.
- W2017759462 cites W2070375844 @default.
- W2017759462 cites W2077624095 @default.
- W2017759462 cites W2081065619 @default.
- W2017759462 cites W2082334073 @default.
- W2017759462 cites W2082854725 @default.
- W2017759462 cites W2086799757 @default.
- W2017759462 cites W2088909919 @default.
- W2017759462 cites W2090965983 @default.
- W2017759462 cites W2091587681 @default.
- W2017759462 cites W2095418258 @default.
- W2017759462 cites W2100784365 @default.
- W2017759462 cites W2102417145 @default.
- W2017759462 cites W2104118842 @default.
- W2017759462 cites W2106590103 @default.
- W2017759462 cites W2112924959 @default.
- W2017759462 cites W2115754584 @default.
- W2017759462 cites W2145822280 @default.
- W2017759462 cites W2146138778 @default.
- W2017759462 cites W2152959849 @default.
- W2017759462 cites W2157930619 @default.
- W2017759462 cites W2161379382 @default.
- W2017759462 cites W2169478814 @default.
- W2017759462 cites W2199386566 @default.
- W2017759462 cites W2405233381 @default.
- W2017759462 cites W2429241442 @default.
- W2017759462 doi "https://doi.org/10.1016/j.ejphar.2007.12.023" @default.
- W2017759462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2346594" @default.
- W2017759462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18242598" @default.
- W2017759462 hasPublicationYear "2008" @default.
- W2017759462 type Work @default.
- W2017759462 sameAs 2017759462 @default.
- W2017759462 citedByCount "15" @default.
- W2017759462 countsByYear W20177594622014 @default.
- W2017759462 countsByYear W20177594622015 @default.
- W2017759462 countsByYear W20177594622017 @default.
- W2017759462 countsByYear W20177594622019 @default.
- W2017759462 countsByYear W20177594622021 @default.
- W2017759462 countsByYear W20177594622022 @default.
- W2017759462 countsByYear W20177594622023 @default.
- W2017759462 crossrefType "journal-article" @default.
- W2017759462 hasAuthorship W2017759462A5005147999 @default.
- W2017759462 hasAuthorship W2017759462A5016267513 @default.
- W2017759462 hasAuthorship W2017759462A5045595920 @default.
- W2017759462 hasAuthorship W2017759462A5052895314 @default.
- W2017759462 hasAuthorship W2017759462A5052939200 @default.
- W2017759462 hasAuthorship W2017759462A5066716873 @default.
- W2017759462 hasAuthorship W2017759462A5069741153 @default.
- W2017759462 hasBestOaLocation W20177594622 @default.
- W2017759462 hasConcept C116289061 @default.
- W2017759462 hasConcept C148001335 @default.
- W2017759462 hasConcept C170493617 @default.
- W2017759462 hasConcept C185592680 @default.