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- W2017761796 abstract "Despite nearly five decades of investigating numerous agents and regimens, there is no curative cytotoxic chemotherapy for advanced, metastatic, breast cancer. Total response rates of 45-80% and complete response rates of 5-25% can be achieved, but median duration of response is 5-13 months and median survival is 15-33 months (I). Chemotherapy as an adjuvant to surgery has been shown to produce a 19-33% improvement in relapse-free and a IO-26% improvement in overall survival in patients with early, operable, breast cancer (2). The majority of patients with early breast cancer so treated, however, will not be cured. Multiple biochemical mechanisms could account for the resistance of a tumor to cytoxic agents; for drug-sensitive cancers, the critical factor in preventing cure may be inadequate dosing. The importance of dose in breast cancer chemotherapy has been extensively debated (3-7). Much attention has focused on the use of very high doses of chemotherapy, doses up to the point that bone marrow ablation is produced. The impetus for evaluating this approach in breast cancer derives primarily from its success in treating refractory hematologic malignancies. High-dose chemotherapy has now been evaluated clinically for more than a decade, and breast cancer is now the malignancy for which this approach is most commonly being used. This commentary reviews laboratory and clinical evidence supporting dose-intensification, the rationale for high-dose chemotherapy, the results of recently reported clinical trials, and the programmes currently under investigation." @default.
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- W2017761796 title "High-dose chemotherapy for breast cancer" @default.
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- W2017761796 doi "https://doi.org/10.1016/0305-7372(95)90000-4" @default.
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