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• W2017768282 abstract "In contrast to IgG Fe receptor II (FcγRIIa), the function of Src-family kinases, Syk and phosphoinositide 3-kinase (P13K) in signal transduction of glycosylphosphatidylinositol-anchored FcγRIIIb has not been analyzed in detail.Therefore pharmacological inhibitors were used to define the role of specific kinases in signalling of FcγRIIa and FcγRIIIb in myeloid cells.We demonstrate that the broad ryrosine kinase inhibitor genistein, the Src-family kinase inhibitor PP2, and the Syk kinase inhibitor piceatannol inhibit [Ca2+]i rise induced by both low-affinity FcγR in neutrophils.Genistein and PP2 additionally prevent FcγR-triggered hydrogen peroxide generation.In contrast, wortmannin, a PI3K inhibitor, which blocks FcγRIIIb activation completely, abolishes FcγRIIa-mediated [Ca2+]i flux only in the beginning.In addition, herbimycin A, a further specific inhibitor of Src-family kinases leads to a delayed FcγRIIa-induced [Ca2+]i rise in THP-1 cells.In summary, our data demonstrate differences between both low-affinity IgG Fe receptors, and provide evidence for an essential role of Src-family kinases, Syk and PI3K in FcγRIIIb-mediated signalling." @default.
• W2017768282 created "2016-06-24" @default.
• W2017768282 creator A5017181843 @default.
• W2017768282 creator A5036911759 @default.
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• W2017768282 date "2001-05-01" @default.
• W2017768282 modified "2023-10-15" @default.
• W2017768282 title "Signal Transduction via Both Human Low-Affinity lgG Fe Receptors, FcγRIIa and FcγRIIIb, Depends on the Activity of Different Families of Intracellular Kinases" @default.
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• W2017768282 doi "https://doi.org/10.1016/s0171-2985(01)80011-5" @default.
• W2017768282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11402496" @default.
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