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- W2017770412 abstract "A full length α-subunit of the Ca2+-activated K+(BK) channel with an inactivating mutation in the C-terminus can complement a functional C-terminal fragment. We analyzed deletions and amino acid changes within the S8–S9 interdomain region for their ability to allow complementation. Cys612and His616that are located in a region that contains two overlapping signature sequences, a immunoglobulin signature sequence and a heme binding domain, are essential for a functional channel. These two amino acid residues are also essential for complementation. The deletion of the PEST sequence does not affect the function of the BK channel; however, without the PEST sequence, complementation by a functional C-terminal fragments is no longer possible. The ability to complement a functional channel is restricted to the C-terminal fragment and requires that the complete α-subunit or the larger N-terminal fragment contains both, the immunoglobulin signature sequence the PEST sequence." @default.
- W2017770412 created "2016-06-24" @default.
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- W2017770412 date "1997-11-01" @default.
- W2017770412 modified "2023-10-18" @default.
- W2017770412 title "Mutations and Deletions within the S8–S9 Interdomain Region Abolish Complementation of N- and C-Terminal Domains of Ca2+-Activated K+(BK) Channels" @default.
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- W2017770412 doi "https://doi.org/10.1006/bbrc.1997.7714" @default.
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