FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017771149> ?p ?o ?g. }

• W2017771149 endingPage "670" @default.
• W2017771149 startingPage "663" @default.
• W2017771149 abstract "Summary A commercially available disk diffusion procedure was used in a large-scale study to evaluate the susceptibility of a wide range of Candida isolates to polyenes and azoles. With almost all isolates of C. glabrata resistant colonies were present within the inhibition zones for the azole compounds fluconazole, ketoconazole and miconazole, and less frequently for isoconazole, econazole and clotrimazole. Ten randomly selected isolates were cloned by limiting dilution and the susceptibility of the resulting strains to polyenes and azoles was determined. All strains presented a similar susceptibility pattern with sensitivity to polyenes and the presence of resistant colonies for all azole compounds except tioconazole. For each strain and each antifungal agent, one of these resistant colonies was subcultured and studied for antifungal susceptibility. All these colonies showed similar properties regardless of which antifungal agent allowed their selection, with increased sensitivity to polyenes and cross-resistance to the azole compounds except tioconazole. Similar results were obtained on Shadomy's modified medium and on synthetic medium. Likewise, determination of MICs by the Etest method confirmed the resistance to fluconazole. Comparative growth studies revealed a respiratory deficiency in the mutants caused by mitochondrial DNA (mtDNA) deletions. In addition, ‘petite’ mutants were obtained from a wild-type strain by exposure to ethidium bromide, and these respiratory mutants were shown to be resistant to azoles. These results demonstrate the relationship between mtDNA deficiency and resistance to azoles, and provide an interesting model to study the mechanisms of action of these antifungal agents." @default.
• W2017771149 created "2016-06-24" @default.
• W2017771149 creator A5015148104 @default.
• W2017771149 creator A5019774075 @default.
• W2017771149 creator A5032125325 @default.
• W2017771149 creator A5039602690 @default.
• W2017771149 creator A5042226152 @default.
• W2017771149 creator A5065970699 @default.
• W2017771149 date "1999-07-01" @default.
• W2017771149 modified "2023-10-18" @default.
• W2017771149 title "In-vitro resistance to azoles associated with mitochondrial DNA deficiency in Candida glabrata" @default.
• W2017771149 cites W1510432475 @default.
• W2017771149 cites W18560267 @default.
• W2017771149 cites W1976768497 @default.
• W2017771149 cites W1985925706 @default.
• W2017771149 cites W1989315617 @default.
• W2017771149 cites W1990776991 @default.
• W2017771149 cites W1993660859 @default.
• W2017771149 cites W1996225900 @default.
• W2017771149 cites W2005360569 @default.
• W2017771149 cites W2006804604 @default.
• W2017771149 cites W2007542228 @default.
• W2017771149 cites W2010842439 @default.
• W2017771149 cites W2037155051 @default.
• W2017771149 cites W2046157585 @default.
• W2017771149 cites W2072139865 @default.
• W2017771149 cites W2090713512 @default.
• W2017771149 cites W2104136879 @default.
• W2017771149 cites W2107013040 @default.
• W2017771149 cites W2115130703 @default.
• W2017771149 cites W2126652150 @default.
• W2017771149 cites W2133291509 @default.
• W2017771149 cites W2136209069 @default.
• W2017771149 cites W2142450445 @default.
• W2017771149 cites W2150252559 @default.
• W2017771149 cites W2168544211 @default.
• W2017771149 cites W2324074896 @default.
• W2017771149 cites W2328377514 @default.
• W2017771149 cites W2341266869 @default.
• W2017771149 cites W2406293470 @default.
• W2017771149 cites W1966496737 @default.
• W2017771149 doi "https://doi.org/10.1099/00222615-48-7-663" @default.
• W2017771149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10403417" @default.
• W2017771149 hasPublicationYear "1999" @default.
• W2017771149 type Work @default.
• W2017771149 sameAs 2017771149 @default.
• W2017771149 citedByCount "56" @default.
• W2017771149 countsByYear W20177711492012 @default.
• W2017771149 countsByYear W20177711492013 @default.
• W2017771149 countsByYear W20177711492014 @default.
• W2017771149 countsByYear W20177711492016 @default.
• W2017771149 countsByYear W20177711492017 @default.
• W2017771149 countsByYear W20177711492019 @default.
• W2017771149 countsByYear W20177711492020 @default.
• W2017771149 countsByYear W20177711492021 @default.
• W2017771149 crossrefType "journal-article" @default.
• W2017771149 hasAuthorship W2017771149A5015148104 @default.
• W2017771149 hasAuthorship W2017771149A5019774075 @default.
• W2017771149 hasAuthorship W2017771149A5032125325 @default.
• W2017771149 hasAuthorship W2017771149A5039602690 @default.
• W2017771149 hasAuthorship W2017771149A5042226152 @default.
• W2017771149 hasAuthorship W2017771149A5065970699 @default.
• W2017771149 hasBestOaLocation W20177711491 @default.
• W2017771149 hasConcept C2776907736 @default.
• W2017771149 hasConcept C2777229883 @default.
• W2017771149 hasConcept C2778080818 @default.
• W2017771149 hasConcept C2779548794 @default.
• W2017771149 hasConcept C2780315139 @default.
• W2017771149 hasConcept C2780651595 @default.
• W2017771149 hasConcept C2780670043 @default.
• W2017771149 hasConcept C2781064554 @default.
• W2017771149 hasConcept C501593827 @default.
• W2017771149 hasConcept C552990157 @default.
• W2017771149 hasConcept C55493867 @default.
• W2017771149 hasConcept C81396022 @default.
• W2017771149 hasConcept C86803240 @default.
• W2017771149 hasConcept C89423630 @default.
• W2017771149 hasConceptScore W2017771149C2776907736 @default.
• W2017771149 hasConceptScore W2017771149C2777229883 @default.
• W2017771149 hasConceptScore W2017771149C2778080818 @default.
• W2017771149 hasConceptScore W2017771149C2779548794 @default.
• W2017771149 hasConceptScore W2017771149C2780315139 @default.
• W2017771149 hasConceptScore W2017771149C2780651595 @default.
• W2017771149 hasConceptScore W2017771149C2780670043 @default.
• W2017771149 hasConceptScore W2017771149C2781064554 @default.
• W2017771149 hasConceptScore W2017771149C501593827 @default.
• W2017771149 hasConceptScore W2017771149C552990157 @default.
• W2017771149 hasConceptScore W2017771149C55493867 @default.
• W2017771149 hasConceptScore W2017771149C81396022 @default.
• W2017771149 hasConceptScore W2017771149C86803240 @default.
• W2017771149 hasConceptScore W2017771149C89423630 @default.
• W2017771149 hasIssue "7" @default.
• W2017771149 hasLocation W20177711491 @default.
• W2017771149 hasLocation W20177711492 @default.
• W2017771149 hasOpenAccess W2017771149 @default.
• W2017771149 hasPrimaryLocation W20177711491 @default.
• W2017771149 hasRelatedWork W2017771149 @default.
• W2017771149 hasRelatedWork W2073334187 @default.

• next