FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017782086> ?p ?o ?g. }

• W2017782086 endingPage "e106246" @default.
• W2017782086 startingPage "e106246" @default.
• W2017782086 abstract "Efforts to develop peripheral blood-derived nature killer (NK) cells into therapeutic products have been hampered by these cells' low abundance and histoincompatibility. On the other hand, derivation of NK-like cells from more abundant cell sources such as embryonic stem cells (ESCs) and umbilical cord blood (UCB) requires the selection of rare CD34+ cells. Thus, we sought to convert adipose-derived stem cells (ADSCs), which are abundant and natively CD34+, into NK-like cells. When grown in hematopoietic induction medium, ADSCs formed sphere clusters and expressed hematopoietic markers CD34, CD45, and KDR. Further induction in NK cell-specific medium resulted in a population of cells that expressed NK cell marker CD56, and thus termed ADSC-NK. Alternatively, the hematopoietically induced ADSCs were transduced with NK cell-specific transcription factor E4BP4 prior to induction in NK cell-specific medium. This latter population of cells, termed ADSC-NKE, expressed CD56 and additional NK cell markers such as CD16, CD94, CD158, CD314, FasL, and NKp46. ADSC-NKE was as potent as NK leukemia cell NKL in killing breast cancer cell MCF7 and prostate cancer cells DU145, PC3, LnCap, DuPro, C4–2 and CWR22, but exhibited no killing activity toward normal endothelial and smooth muscle cells. In nude mice test ADSC-NKE was able to significantly delay the progression of tumors formed by MCF7 and PC3. When injected into immunocompetent rats, ADSC-NKE was detectable in bone marrow and spleen for at least 5 weeks. Together, these results suggest that ADSCs can be converted into NK-like cells with anti-tumor activities." @default.
• W2017782086 created "2016-06-24" @default.
• W2017782086 creator A5001623694 @default.
• W2017782086 creator A5017254585 @default.
• W2017782086 creator A5028497420 @default.
• W2017782086 creator A5051298638 @default.
• W2017782086 creator A5054667123 @default.
• W2017782086 creator A5072773646 @default.
• W2017782086 creator A5081192418 @default.
• W2017782086 creator A5090856147 @default.
• W2017782086 creator A5091637974 @default.
• W2017782086 date "2014-08-27" @default.
• W2017782086 modified "2023-09-23" @default.
• W2017782086 title "Conversion of Adipose-Derived Stem Cells into Natural Killer-Like Cells with Anti-Tumor Activities in Nude Mice" @default.
• W2017782086 cites W1591435741 @default.
• W2017782086 cites W1964227876 @default.
• W2017782086 cites W1966426962 @default.
• W2017782086 cites W1985761935 @default.
• W2017782086 cites W1987184611 @default.
• W2017782086 cites W1992003374 @default.
• W2017782086 cites W1996353134 @default.
• W2017782086 cites W2004768960 @default.
• W2017782086 cites W2005283688 @default.
• W2017782086 cites W2011221892 @default.
• W2017782086 cites W2015333667 @default.
• W2017782086 cites W2015938431 @default.
• W2017782086 cites W2019364542 @default.
• W2017782086 cites W2022069273 @default.
• W2017782086 cites W2030712896 @default.
• W2017782086 cites W2038022281 @default.
• W2017782086 cites W2040478897 @default.
• W2017782086 cites W2048109221 @default.
• W2017782086 cites W2055361585 @default.
• W2017782086 cites W2060829712 @default.
• W2017782086 cites W2068578516 @default.
• W2017782086 cites W2081047303 @default.
• W2017782086 cites W2093006514 @default.
• W2017782086 cites W2097050852 @default.
• W2017782086 cites W2104626232 @default.
• W2017782086 cites W2113417184 @default.
• W2017782086 cites W2115115786 @default.
• W2017782086 cites W2127944870 @default.
• W2017782086 cites W2138708037 @default.
• W2017782086 cites W2138992037 @default.
• W2017782086 cites W2164762604 @default.
• W2017782086 doi "https://doi.org/10.1371/journal.pone.0106246" @default.
• W2017782086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4146612" @default.
• W2017782086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25162225" @default.
• W2017782086 hasPublicationYear "2014" @default.
• W2017782086 type Work @default.
• W2017782086 sameAs 2017782086 @default.
• W2017782086 citedByCount "13" @default.
• W2017782086 countsByYear W20177820862015 @default.
• W2017782086 countsByYear W20177820862017 @default.
• W2017782086 countsByYear W20177820862018 @default.
• W2017782086 countsByYear W20177820862019 @default.
• W2017782086 countsByYear W20177820862020 @default.
• W2017782086 countsByYear W20177820862021 @default.
• W2017782086 countsByYear W20177820862022 @default.
• W2017782086 countsByYear W20177820862023 @default.
• W2017782086 crossrefType "journal-article" @default.
• W2017782086 hasAuthorship W2017782086A5001623694 @default.
• W2017782086 hasAuthorship W2017782086A5017254585 @default.
• W2017782086 hasAuthorship W2017782086A5028497420 @default.
• W2017782086 hasAuthorship W2017782086A5051298638 @default.
• W2017782086 hasAuthorship W2017782086A5054667123 @default.
• W2017782086 hasAuthorship W2017782086A5072773646 @default.
• W2017782086 hasAuthorship W2017782086A5081192418 @default.
• W2017782086 hasAuthorship W2017782086A5090856147 @default.
• W2017782086 hasAuthorship W2017782086A5091637974 @default.
• W2017782086 hasBestOaLocation W20177820861 @default.
• W2017782086 hasConcept C10205521 @default.
• W2017782086 hasConcept C109159458 @default.
• W2017782086 hasConcept C129374314 @default.
• W2017782086 hasConcept C136302470 @default.
• W2017782086 hasConcept C149532602 @default.
• W2017782086 hasConcept C154317977 @default.
• W2017782086 hasConcept C202751555 @default.
• W2017782086 hasConcept C203014093 @default.
• W2017782086 hasConcept C206191192 @default.
• W2017782086 hasConcept C2776090121 @default.
• W2017782086 hasConcept C2778867473 @default.
• W2017782086 hasConcept C2780007613 @default.
• W2017782086 hasConcept C28328180 @default.
• W2017782086 hasConcept C28651165 @default.
• W2017782086 hasConcept C2908647359 @default.
• W2017782086 hasConcept C502942594 @default.
• W2017782086 hasConcept C55493867 @default.
• W2017782086 hasConcept C71924100 @default.
• W2017782086 hasConcept C86803240 @default.
• W2017782086 hasConcept C8891405 @default.
• W2017782086 hasConcept C95444343 @default.
• W2017782086 hasConcept C99454951 @default.
• W2017782086 hasConceptScore W2017782086C10205521 @default.
• W2017782086 hasConceptScore W2017782086C109159458 @default.
• W2017782086 hasConceptScore W2017782086C129374314 @default.
• W2017782086 hasConceptScore W2017782086C136302470 @default.
• W2017782086 hasConceptScore W2017782086C149532602 @default.

• next