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• W2017782289 abstract "This study focuses on the synaptic output patterns of thalamocortical axons in mouse barrel cortex at postnatal day (P) 11. Axons were labeled by biotinylated dextran amine transported anterogradely following injection in vivo into the ventrobasal thalamus. Labeled axons in the posteromedial barrel subfield were examined by light and electron microscopy and then reconstructed in three dimensions to assess the spatial distribution of their synapses. Thalamocortical axons form asymmetrical synapses, both at varicosities and along cylindrical portions of the axons; usually, only one synapse occurs per site, contrasting with the case in the adult, in which multiple synapses are typical. At P11, varicosities without synapses are common. As in adult barrels, approximately 80% of synapses formed by thalamocortical axons are with dendritic spines; 20% are with dendritic shafts. The similarity in the distribution of thalamocortical synapses onto spines vs. dendrites in developing and mature barrels indicates that adult synaptic patterns already are specified at a very early stage of thalamocortical synaptogenesis." @default.
• W2017782289 created "2016-06-24" @default.
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• W2017782289 date "2002-01-01" @default.
• W2017782289 modified "2023-09-24" @default.
• W2017782289 title "Synaptic patterns of thalamocortical afferents in mouse barrels at postnatal day 11" @default.
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• W2017782289 doi "https://doi.org/10.1002/cne.1422" @default.
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