Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017790777> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2017790777 endingPage "2343" @default.
- W2017790777 startingPage "2339" @default.
- W2017790777 abstract "Azacitidine (AZA) is the current treatment for patients with high-risk myelodysplastic syndrome, but resistance is a common feature of AZA-treated patients. To investigate the mechanisms associated with AZA resistance in vitro, we generated AZA-resistant SKM1 myeloid cells, called hereafter AZA-R. AZA-R cells exhibit impaired mitochondrial membrane permeabilization and caspase activation in response to AZA compared to their AZA-sensitive (AZA-S) counterpart. AZA induced LC3-II accumulation and cathepsin B activity in AZA-S cells, two hallmarks of autophagy. AZA-R cells displayed increased basal autophagy but are resistant to AZA-mediated autophagy. Inhibition of autophagy using LC3 siRNA revealed that autophagy is protective in AZA-S cells and AZA-R cells in basal conditions. By contrast, AZA-R cells exhibited impaired autophagy in response to AZA. Collectively, our findings indicate that AZA promotes apoptosis and autophagy in SKM1 cells, and that AZA-R cells are resistant to both apoptosis and autophagy induced by AZA." @default.
- W2017790777 created "2016-06-24" @default.
- W2017790777 creator A5016341726 @default.
- W2017790777 creator A5029424482 @default.
- W2017790777 creator A5038903944 @default.
- W2017790777 creator A5039959145 @default.
- W2017790777 creator A5051365781 @default.
- W2017790777 creator A5076906680 @default.
- W2017790777 creator A5080661528 @default.
- W2017790777 date "2011-07-15" @default.
- W2017790777 modified "2023-09-23" @default.
- W2017790777 title "Azacitidine-resistant SKM1 myeloid cells are defective for AZA-induced mitochondrial apoptosis and autophagy" @default.
- W2017790777 doi "https://doi.org/10.4161/cc.10.14.16308" @default.
- W2017790777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21654192" @default.
- W2017790777 hasPublicationYear "2011" @default.
- W2017790777 type Work @default.
- W2017790777 sameAs 2017790777 @default.
- W2017790777 citedByCount "27" @default.
- W2017790777 countsByYear W20177907772012 @default.
- W2017790777 countsByYear W20177907772014 @default.
- W2017790777 countsByYear W20177907772015 @default.
- W2017790777 countsByYear W20177907772016 @default.
- W2017790777 countsByYear W20177907772017 @default.
- W2017790777 countsByYear W20177907772018 @default.
- W2017790777 countsByYear W20177907772019 @default.
- W2017790777 countsByYear W20177907772022 @default.
- W2017790777 crossrefType "journal-article" @default.
- W2017790777 hasAuthorship W2017790777A5016341726 @default.
- W2017790777 hasAuthorship W2017790777A5029424482 @default.
- W2017790777 hasAuthorship W2017790777A5038903944 @default.
- W2017790777 hasAuthorship W2017790777A5039959145 @default.
- W2017790777 hasAuthorship W2017790777A5051365781 @default.
- W2017790777 hasAuthorship W2017790777A5076906680 @default.
- W2017790777 hasAuthorship W2017790777A5080661528 @default.
- W2017790777 hasBestOaLocation W20177907771 @default.
- W2017790777 hasConcept C104317684 @default.
- W2017790777 hasConcept C150194340 @default.
- W2017790777 hasConcept C190283241 @default.
- W2017790777 hasConcept C190727270 @default.
- W2017790777 hasConcept C203522944 @default.
- W2017790777 hasConcept C2776239401 @default.
- W2017790777 hasConcept C2778729363 @default.
- W2017790777 hasConcept C2779282312 @default.
- W2017790777 hasConcept C28859421 @default.
- W2017790777 hasConcept C2994430510 @default.
- W2017790777 hasConcept C502942594 @default.
- W2017790777 hasConcept C54355233 @default.
- W2017790777 hasConcept C86803240 @default.
- W2017790777 hasConcept C95444343 @default.
- W2017790777 hasConceptScore W2017790777C104317684 @default.
- W2017790777 hasConceptScore W2017790777C150194340 @default.
- W2017790777 hasConceptScore W2017790777C190283241 @default.
- W2017790777 hasConceptScore W2017790777C190727270 @default.
- W2017790777 hasConceptScore W2017790777C203522944 @default.
- W2017790777 hasConceptScore W2017790777C2776239401 @default.
- W2017790777 hasConceptScore W2017790777C2778729363 @default.
- W2017790777 hasConceptScore W2017790777C2779282312 @default.
- W2017790777 hasConceptScore W2017790777C28859421 @default.
- W2017790777 hasConceptScore W2017790777C2994430510 @default.
- W2017790777 hasConceptScore W2017790777C502942594 @default.
- W2017790777 hasConceptScore W2017790777C54355233 @default.
- W2017790777 hasConceptScore W2017790777C86803240 @default.
- W2017790777 hasConceptScore W2017790777C95444343 @default.
- W2017790777 hasIssue "14" @default.
- W2017790777 hasLocation W20177907771 @default.
- W2017790777 hasOpenAccess W2017790777 @default.
- W2017790777 hasPrimaryLocation W20177907771 @default.
- W2017790777 hasRelatedWork W1529272180 @default.
- W2017790777 hasRelatedWork W1967888239 @default.
- W2017790777 hasRelatedWork W1973586971 @default.
- W2017790777 hasRelatedWork W2002675829 @default.
- W2017790777 hasRelatedWork W2012915254 @default.
- W2017790777 hasRelatedWork W2027274431 @default.
- W2017790777 hasRelatedWork W214686084 @default.
- W2017790777 hasRelatedWork W2581455006 @default.
- W2017790777 hasRelatedWork W2805121851 @default.
- W2017790777 hasRelatedWork W3162856407 @default.
- W2017790777 hasVolume "10" @default.
- W2017790777 isParatext "false" @default.
- W2017790777 isRetracted "false" @default.
- W2017790777 magId "2017790777" @default.
- W2017790777 workType "article" @default.