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- W2017795026 abstract "We report here a 47-year-old woman with isolated adrenocorticotropin (ACTH) deficiency (IAD). She presented impaired renin-angiotensin-aldosterone (R-A-A) system and suppressed parathyroid hormone (PTH)-vitamin D system. She showed severe hyponatremia due to secondary adrenocortical insufficiency, which was deteriorated by hypoaldosteronism. She also showed hyperphosphatemia and relative hypercalcemia with suppressed PTH-vitamin D axis. Moreover, she showed hypothyroidism, which was thought to be important to maintain normal Ca levels under secondary hypoadrenalism via decrease in bone resorption by T3. Replacement with glucocorticoid completely normalized PTH-vitamin D axis and R-A-A system. Thus, the present case implicates that severe adrenocortical deficiency due to IAD might affect both R-A-A system and PTH-vitamin D axis. These findings suggest that the ACTH-cortisol axis has an important role in mineral metabolism in vivo." @default.
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- W2017795026 date "2002-01-01" @default.
- W2017795026 modified "2023-09-23" @default.
- W2017795026 title "Isolated Adrenocorticotropin Deficiency Presenting with Impaired Renin-Angiotensin-Aldosterone System and Suppressed Parathyroid Hormone-Vitamin D Axis." @default.
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- W2017795026 doi "https://doi.org/10.2169/internalmedicine.41.561" @default.
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