FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017797542> ?p ?o ?g. }

• W2017797542 endingPage "877" @default.
• W2017797542 startingPage "870" @default.
• W2017797542 abstract "Summary Introduction The postprandial lipid metabolism in metabolic syndrome patients is disturbed and may add to the increased cardiovascular risk in these patients. It is not known whether postprandial high density lipoprotein‐cholesterol (HDL‐c) metabolism is also affected and whether this can be influenced by statin and/or ezetimibe treatment. Methods Prospective, randomized, double blind, crossover trial comparing simvastatin 80 mg with simvastatin/ezetimibe 10 mg/10 mg treatment for 6 weeks on postprandial HDL‐c metabolism in 15, nonsmoking, male, obese metabolic syndrome patients (Adult Treatment Panel III, ATPIII). Only study medication was allowed. HDL‐c concentrations, cholesteryl ester transfer (CET), CET protein (CETP) mass and adiponectin were measured before and after oral fat loading. ClinicalTrials.gov NCT00189085. Results Plasma HDL‐c levels remained stable during continuous fasting following an overnight fast. Pre‐fat load HDL‐c concentrations without treatment, after simvastatin and simvastatin/ezetimibe treatment were 1·15 ± 0·04, 1·16 ± 0·05 and 1·11 ± 0·04 mmol/l. Fat load induced a 11% drop in HDL‐c plasma levels; 1·02 ± 0·05 mmol/l ( P < 0·001) which was not affected by either therapy. Triglyceride levels during fat load were similar after both treatments. Total CET increased from 9·73 ± 0·70 to 12·20 ± 0·67 nmol/ml/h ( P = 0·004). Four hours after fat loading CETP mass was increased while adiponectin levels were decreased, irrespective of treatment. Discussion HDL‐c levels decrease as CET increases after fat loading in obese metabolic syndrome patients. This is not influenced by either simvastatin or simvastatin/ezetimibe treatment. After fat loading, CETP mass and CET increased, and adiponectin decreased pointing towards a potential role for intra‐abdominal fat. Decreased postprandial HDL‐c levels may contribute to the increased cardiovascular risk in metabolic syndrome patients on top of already low HDL‐c levels." @default.
• W2017797542 created "2016-06-24" @default.
• W2017797542 creator A5022429591 @default.
• W2017797542 creator A5060583173 @default.
• W2017797542 creator A5073320977 @default.
• W2017797542 creator A5081795068 @default.
• W2017797542 creator A5088549205 @default.
• W2017797542 date "2008-11-12" @default.
• W2017797542 modified "2023-10-15" @default.
• W2017797542 title "Lipid-lowering therapy does not affect the postprandial drop in high density lipoprotein-cholesterol (HDL-c) plasma levels in obese men with metabolic syndrome: a randomized double blind crossover trial" @default.
• W2017797542 cites W1510710298 @default.
• W2017797542 cites W1942450359 @default.
• W2017797542 cites W1964607854 @default.
• W2017797542 cites W1975768552 @default.
• W2017797542 cites W1975936284 @default.
• W2017797542 cites W1988551619 @default.
• W2017797542 cites W1996256445 @default.
• W2017797542 cites W2011051352 @default.
• W2017797542 cites W2011714633 @default.
• W2017797542 cites W2064608611 @default.
• W2017797542 cites W2064707131 @default.
• W2017797542 cites W2068209188 @default.
• W2017797542 cites W2069610898 @default.
• W2017797542 cites W2073793932 @default.
• W2017797542 cites W2093648180 @default.
• W2017797542 cites W2111170630 @default.
• W2017797542 cites W2131740775 @default.
• W2017797542 cites W2136725827 @default.
• W2017797542 cites W2137991400 @default.
• W2017797542 cites W2158342481 @default.
• W2017797542 cites W2167542744 @default.
• W2017797542 cites W2181591202 @default.
• W2017797542 cites W2286030148 @default.
• W2017797542 cites W4210956151 @default.
• W2017797542 cites W4238251256 @default.
• W2017797542 cites W4252272548 @default.
• W2017797542 cites W4300756237 @default.
• W2017797542 doi "https://doi.org/10.1111/j.1365-2265.2008.03250.x" @default.
• W2017797542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18394022" @default.
• W2017797542 hasPublicationYear "2008" @default.
• W2017797542 type Work @default.
• W2017797542 sameAs 2017797542 @default.
• W2017797542 citedByCount "16" @default.
• W2017797542 countsByYear W20177975422012 @default.
• W2017797542 countsByYear W20177975422013 @default.
• W2017797542 countsByYear W20177975422014 @default.
• W2017797542 countsByYear W20177975422015 @default.
• W2017797542 countsByYear W20177975422017 @default.
• W2017797542 countsByYear W20177975422022 @default.
• W2017797542 crossrefType "journal-article" @default.
• W2017797542 hasAuthorship W2017797542A5022429591 @default.
• W2017797542 hasAuthorship W2017797542A5060583173 @default.
• W2017797542 hasAuthorship W2017797542A5073320977 @default.
• W2017797542 hasAuthorship W2017797542A5081795068 @default.
• W2017797542 hasAuthorship W2017797542A5088549205 @default.
• W2017797542 hasConcept C126322002 @default.
• W2017797542 hasConcept C134018914 @default.
• W2017797542 hasConcept C142724271 @default.
• W2017797542 hasConcept C204787440 @default.
• W2017797542 hasConcept C27081682 @default.
• W2017797542 hasConcept C2776329913 @default.
• W2017797542 hasConcept C2776782570 @default.
• W2017797542 hasConcept C2777391703 @default.
• W2017797542 hasConcept C2778163477 @default.
• W2017797542 hasConcept C2778199505 @default.
• W2017797542 hasConcept C2778657065 @default.
• W2017797542 hasConcept C2778913445 @default.
• W2017797542 hasConcept C2779306644 @default.
• W2017797542 hasConcept C2780072125 @default.
• W2017797542 hasConcept C2780578515 @default.
• W2017797542 hasConcept C45505151 @default.
• W2017797542 hasConcept C511355011 @default.
• W2017797542 hasConcept C71924100 @default.
• W2017797542 hasConcept C87813604 @default.
• W2017797542 hasConceptScore W2017797542C126322002 @default.
• W2017797542 hasConceptScore W2017797542C134018914 @default.
• W2017797542 hasConceptScore W2017797542C142724271 @default.
• W2017797542 hasConceptScore W2017797542C204787440 @default.
• W2017797542 hasConceptScore W2017797542C27081682 @default.
• W2017797542 hasConceptScore W2017797542C2776329913 @default.
• W2017797542 hasConceptScore W2017797542C2776782570 @default.
• W2017797542 hasConceptScore W2017797542C2777391703 @default.
• W2017797542 hasConceptScore W2017797542C2778163477 @default.
• W2017797542 hasConceptScore W2017797542C2778199505 @default.
• W2017797542 hasConceptScore W2017797542C2778657065 @default.
• W2017797542 hasConceptScore W2017797542C2778913445 @default.
• W2017797542 hasConceptScore W2017797542C2779306644 @default.
• W2017797542 hasConceptScore W2017797542C2780072125 @default.
• W2017797542 hasConceptScore W2017797542C2780578515 @default.
• W2017797542 hasConceptScore W2017797542C45505151 @default.
• W2017797542 hasConceptScore W2017797542C511355011 @default.
• W2017797542 hasConceptScore W2017797542C71924100 @default.
• W2017797542 hasConceptScore W2017797542C87813604 @default.
• W2017797542 hasIssue "6" @default.
• W2017797542 hasLocation W20177975421 @default.
• W2017797542 hasLocation W20177975422 @default.
• W2017797542 hasOpenAccess W2017797542 @default.
• W2017797542 hasPrimaryLocation W20177975421 @default.

• next