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• W2017800749 abstract "Transforming growth factor (TGF)-beta stimulation leads to phosphorylation and activation of Smad2 and Smad3, which form complexes with Smad4 that accumulate in the nucleus and regulate transcription of target genes. Here we demonstrate that, following TGF-beta stimulation of epithelial cells, receptors remain active for at least 3-4 hr, and continuous receptor activity is required to maintain active Smads in the nucleus and for TGF-beta-induced transcription. We show that continuous nucleocytoplasmic shuttling of the Smads during active TGF-beta signaling provides the mechanism whereby the intracellular transducers of the signal continuously monitor receptor activity. Our data therefore explain how, at all times, the concentration of active Smads in the nucleus is directly dictated by the levels of activated receptors in the cytoplasm." @default.
• W2017800749 created "2016-06-24" @default.
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• W2017800749 creator A5035380866 @default.
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• W2017800749 date "2002-08-01" @default.
• W2017800749 modified "2023-10-10" @default.
• W2017800749 title "Nucleocytoplasmic Shuttling of Smads 2, 3, and 4 Permits Sensing of TGF-β Receptor Activity" @default.
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• W2017800749 doi "https://doi.org/10.1016/s1097-2765(02)00585-3" @default.
• W2017800749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12191474" @default.
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